Applied Drug Delivery Throughout the Engineering Curriculum

贯穿工程课程的应用药物输送

• 批准号: 0126902
• 负责人: Stephanie Farrell
• 金额: $ 19.43万
• 依托单位: Rowan University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0126902&HistoricalAwards=false
• 关键词: Applied; Drug; Delivery; Throughout; Engineering

Drug Delivery is a burgeoning field that represents one of the major research and development focus areas of the pharmaceutical industry today, with new drug delivery system sales exceeding 10 billion dollars per year. Chemical Engineers play an important and expanding role in this exciting field, yet undergraduate chemical engineering students are rarely exposed to drug delivery through their coursework. To provide students with the skills directly relevant to the evolving needs of the pharmaceutical industry, this project is developing and integrating applied drug delivery coursework and experiments throughout the Rowan Engineering curriculum. The design and production of new drug delivery systems requires that the engineer fully understand the drug and know material properties related to the processing variables that affect the release of the drug. This requires the engineer to have a solid grasp of the fundamentals of mass transfer, reaction kinetics, thermodynamics, and transport phenomena. He or she must also be skilled in characterization techniques and physical property testing of the delivery system, and practiced in the analysis of the drug release data. This project provides the Chemical Engineering students at Rowan University with the necessary foundation materials and fundamental principles. There are seven modules adapted, implemented and used to introduce students to the multidisciplinary engineering principles of common drug delivery systems designs. Each module describes experiments used to support the design, preparation, characterization, and analysis of that particular drug delivery system. The seven drug delivery systems explored are: tablets, ointments, membrane systems, microcapsules, osmotic pumps, Chemical kinetics, and supercritical fluid-processed particles. The engineering goals of this project are:--to explore different types of drug delivery systems--to study drug delivery designs in a quantitative manner using engineering principles--to use up-to-date industrial techniques for the production, testing, and analysis of drug delivery systems and to evaluate factors influencing the release of drug from a delivery system.To accomplish these goals, this collaborative project maximizes the curricular impact by vertically integrating the seven modules beginning with the Freshman Clinic, followed by the fundamental engineering courses, the Junior-Senior research projects course, and finally, advanced level elective courses on pharmaceutical topics. These modules employ proven methods in SMET education. To maintain the quality , recurring meetings of senior project personnel and other Chemical Engineering Department faculty are planned as necessary. The project is undertaking both formative evaluations and summative evaluations, and its dissemination is being accomplished through presentations at national conferences, CD-ROM and refereed journals. Keywords: Drug delivery systems, drug delivery methods, pharmaceutical drug delivery systems

药物输送是一个新兴的领域，代表着当今制药业的主要研发重点领域之一，新药输送系统的年销售额超过100亿美元。化学工程师在这个令人兴奋的领域扮演着重要且不断扩大的角色，但本科生化学工程专业的学生很少在他们的课程中接触到药物输送。为了向学生提供与制药行业不断发展的需求直接相关的技能，该项目正在开发和整合应用药物输送课程和整个罗文工程课程中的实验。新型药物输送系统的设计和生产要求工程师充分了解药物，并了解与影响药物释放的工艺变量相关的材料性质。这要求工程师扎实掌握传质、反应动力学、热力学和传输现象的基本原理。他或她还必须熟练掌握给药系统的表征技术和物理性能测试，并熟练地分析药物释放数据。该项目为罗文大学化学工程专业的学生提供了必要的基础材料和基本原理。有七个模块被改编、实施并用于向学生介绍常见药物输送系统设计的多学科工程原理。每个模块描述用于支持该特定药物输送系统的设计、制备、表征和分析的实验。所研究的七种给药系统是：片剂、软膏、膜系统、微囊、渗透泵、化学动力学和超临界流体处理颗粒。这个项目的工程目标是：-探索不同类型的药物输送系统--用工程学原理定量研究药物输送系统的设计--使用最新的工业技术生产、测试和分析药物输送系统，并评估影响药物从输送系统释放的因素。为了实现这些目标，这个合作项目从新生诊所开始垂直整合七个模块，然后是基础工程课程、初级-高级研究项目课程，最后是关于药学主题的高级选修课程，从而最大限度地发挥课程的影响。这些模块在SMET教育中采用了经过验证的方法。为了保持质量，计划在必要时召开高级项目人员和其他化学工程系教员的定期会议。该项目正在进行形成性评价和总结性评价，并通过在国家会议、光盘和参考期刊上发表演讲来传播该项目。关键词：给药系统、给药方法、药物给药系统