NmlR-dependent thiol-based redox systems and their role in global stress responses in bacteria

NmlR依赖的硫醇基氧化还原系统及其在细菌整体应激反应中的作用

• 批准号: DP0986578
• 负责人: Prof Alastair McEwan
• 金额: $ 20.76万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0986578
• 关键词: NmlR; dependent; thiol; based; redox

All cells sense changes to their environment and respond by altering their metabolism. A major environmental change is oxidative stress which damages cells. Cells have the ability to sense oxidative stress and alter metabolic processes to defend against the damage that it elicits. This proposal will characterize a novel oxidative stress defense system that is found in a number of bacterial pathogens that need to defend themselves against attack by the host. The project may identify new ways to manage these bacterial pathogens. It may also provide an insight into oxidative stress defense processes that are linked to pathologies in humans.

所有的细胞都能感受到环境的变化，并通过改变新陈代谢做出反应。一个主要的环境变化是破坏细胞的氧化应激。细胞有能力感知氧化应激，改变代谢过程，以抵御氧化应激带来的损害。该提案将描述一种新的氧化应激防御系统，该系统存在于许多需要保护自己免受宿主攻击的细菌病原体中。该项目可能会发现管理这些细菌病原体的新方法。它还可以提供与人类病理学相关的氧化应激防御过程的见解。