NmlR-dependent thiol-based redox systems and their role in global stress responses in bacteria

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All cells sense changes to their environment and respond by altering their metabolism. A major environmental change is oxidative stress which damages cells. Cells have the ability to sense oxidative stress and alter metabolic processes to defend against the damage that it elicits. This proposal will characterize a novel oxidative stress defense system that is found in a number of bacterial pathogens that need to defend themselves against attack by the host. The project may identify new ways to manage these bacterial pathogens. It may also provide an insight into oxidative stress defense processes that are linked to pathologies in humans.