Signal transduction and the control of bacterial respiration by the NtrYX two component regulatory system

该提案将定义NtrYX双组分信号转导的结构和功能特性，并定义其在呼吸基因表达调控中的作用。人类病原体淋病奈瑟菌将被用作具有NtrYX的各种“氧化酶阳性”细菌的模式生物。结果将是一个重大的贡献，了解呼吸道基因表达的方式控制的细菌物种，大肠杆菌是不是一个合适的模型。

This proposal will define the structural and functional properties of the NtrYX two component signal transduction and define its role in the regulation of respiratory gene expression. The human pathogen Neisseria gonorrhoeae will be used as a model organism for a diverse range of 'oxidase positive' bacteria that possess NtrYX. The outcome will be a major contribution to the understanding of way in which respiratory gene expression is controlled in bacterial species for which Escherichia coli is not a suitable model.