Signal transduction and the control of bacterial respiration by the NtrYX two component regulatory system

NtrYX 二组分调节系统的信号转导和细菌呼吸控制

• 批准号: DP140102139
• 负责人: Prof Alastair McEwan
• 金额: $ 20.97万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140102139
• 关键词: Signal; transduction; control; bacterial; respiration

This proposal will define the structural and functional properties of the NtrYX two component signal transduction and define its role in the regulation of respiratory gene expression. The human pathogen Neisseria gonorrhoeae will be used as a model organism for a diverse range of 'oxidase positive' bacteria that possess NtrYX. The outcome will be a major contribution to the understanding of way in which respiratory gene expression is controlled in bacterial species for which Escherichia coli is not a suitable model.

本提案将定义NtrYX双组分信号转导的结构和功能特性，并定义其在调节呼吸基因表达中的作用。人类病原体淋病奈瑟菌将被用作具有NtrYX的多种“氧化酶阳性”细菌的模式生物。结果将是一个重要的贡献，以了解呼吸基因表达的方式是控制细菌物种，大肠杆菌不是一个合适的模型。