CISE Research Resources: Computer cluster to support computational biology and other nonlinear signal reconstruction and system design problems

0130538彼得·多尔舒克·普渡大学研究资源：支持计算生物学和其他非线性信号重建和系统设计问题的计算机集群这笔赠款是一项设备赠款，将购买两台计算机、一台计算机服务器和一台3-D可视化工作站，以支持研究人员在计算数学及其在病毒结构生物学和其他非线性信号重建和系统设计问题上的应用。计算服务器(MicroWay，Inc.)是一台集群计算机，包含英特尔奔腾III微处理器和16 GB内存，组成32个节点，通过100Mb以太网连接。可视化工作站(Sun MicroSystems)是一台配备900 MHz UltraSPARC-III微处理器、1 GB内存的工作站，是Sun的三级三维图形硬件加速器中的中间级。该设备将支持3个涉及计算数学的项目，包括多维求积、变换和数值优化。统一的主题是数值优化，特别是全局优化。这些项目按应用进行划分，包括结构生物学中的三维重建问题和非线性通信信道的系统设计问题。它的主要应用是结构生物学，特别是病毒的结构生物学。特别令人感兴趣的问题是三维信号重建问题，用于从各种生物物理测量中计算病毒的动态行为。

0130538 Peter DoerschukPurdue UniversityCISE Research Resources: Computer Cluster to Support Computational Biology and Other Nonlinear Signal Reconstruction and System Design ProblemsThe grant, an equipment grant, will purchase two computers, a compute server and a 3-D visualization workstation, in support of the investigators' NSF CISE funded work in computational mathematics and its application to the structural biology of viruses and other nonlinear signal reconstruction and system design problems. The compute server (Microway, Inc.) is a cluster computer containing 64 Intel Pentium III microprocessors and 16 GB of memory organized into 32 nodes connected by 100 Mb Ethernet. The visualization workstation (Sun Microsystems) is a workstation with one 900 MHz UltraSPARC-III microprocessor, 1 GB of memory, and the intermediate level of Sun's three levels of 3-D graphics hardware accelerators.This equipment will support 3 projects which concern computational mathematics including multi-dimensional quadratures, transforms, and numerical optimization. The unifying theme is numerical optimization, especially global optimization. The projects are divided according to application and include 3-D reconstruction problems in structural biology and systems design problems for nonlinear communication channels. The main application is structural biology, in particular, the structural biology of viruses. The problems of particular interest are 3-D signal reconstruction problems for computing the dynamical behavior of viruses from a variety of biophysical measurements.