CAREER: Development of Polymerizable Diacetylene Surfactant Monomers for Two-Dimensional Imprinting and Sensors

该奖项授予路易斯安那州立大学化学系的先进材料项目。获得这一职业奖后，David Spivak教授将设计、合成、加工和表征具有印迹识别和转导位点的聚合物单分子膜。具有不同头部基团的表面活性剂二乙炔单体将在空气-水界面上与水相中的蛋白质有序和取向，以便在单体被紫外光聚合之前为其提供识别位置。响应分析物结合/解离的可逆信号转导将通过比色法、电化学法、紫外可见或荧光法由聚合物单分子膜直接检测，这些单分子膜可发展为用于特定生物和化学检测的器件和传感器。在该部门的支持下，该研究所将开发一项纳米科学的多学科计划，重点是化学、生物和工程。此外，一个新的包含教学和动手实验室课程的高分子研究课程将重新启动，并向研究生和本科生提供。基于不同头部基团的聚二乙炔的单分子膜将被设计、合成、加工和表征，以期在生物和化学传感器和器件中有潜在的应用。此外，这些对分析物具有特定识别位置的单分子膜将具有可逆的信号转导特性，信号可以通过比色、电化学、紫外可见或荧光方法进行处理。作为教育计划的一部分，将为研究生和本科生提供一个包含培训和研究机会的多学科计划。

The Advanced Materials Program in the Division of Chemistry makes this award to Louisianan State University. With this Career award, Professor David Spivak will design, synthesize, process and characterize polymer monolayers with imprinted recognition and transduction sites. Surfactant diacetylene monomers with different head groups will be ordered and oriented at the air-water interface with proteins in the water sub-phase to provide recognition sites for the monomers before they are polymerized by ultraviolet radiation. Reversible signal transduction in response to binding/unbinding of analytes will be detected directly by the polymer monolayer by colorimetric, electrochemical, uv-visible or fluorescence methods, and these monolayers may be developed to devices and sensors for specific biological and chemical detection. The PI with the support from the department will develop a multidisciplinary program in nanoscale sciences with special emphases on Chemistry, Biology and Engineering. In addition, a new Macromolecular Studies program with teaching and hand-on laboratory courses will be reactivated and offered to both graduate and undergraduate students. Monolayers based on polydiacetylene with different head groups will be designed, synthesized, processed and characterized for potential application in bio- and chemical-sensors and devices. In addition, these monolayers with specific recognition sites for analytes will have reversible signal transduction properties and signal may be processed by colorimetric, electrochemical, uv-visible or fluorescence methods. As part of the education program, a multidisciplinary program with training and research opportunities will be offered to both graduate and undergraduate students.