CAREER: Development of Polymerizable Diacetylene Surfactant Monomers for Two-Dimensional Imprinting and Sensors

职业：开发用于二维压印和传感器的可聚合二乙炔表面活性剂单体

• 批准号: 0134290
• 负责人: David Spivak
• 金额: $ 36.08万
• 依托单位: Louisiana State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0134290&HistoricalAwards=false
• 关键词: CAREER; Development; Polymerizable; Diacetylene; Surfactant

The Advanced Materials Program in the Division of Chemistry makes this award to Louisianan State University. With this Career award, Professor David Spivak will design, synthesize, process and characterize polymer monolayers with imprinted recognition and transduction sites. Surfactant diacetylene monomers with different head groups will be ordered and oriented at the air-water interface with proteins in the water sub-phase to provide recognition sites for the monomers before they are polymerized by ultraviolet radiation. Reversible signal transduction in response to binding/unbinding of analytes will be detected directly by the polymer monolayer by colorimetric, electrochemical, uv-visible or fluorescence methods, and these monolayers may be developed to devices and sensors for specific biological and chemical detection. The PI with the support from the department will develop a multidisciplinary program in nanoscale sciences with special emphases on Chemistry, Biology and Engineering. In addition, a new Macromolecular Studies program with teaching and hand-on laboratory courses will be reactivated and offered to both graduate and undergraduate students. Monolayers based on polydiacetylene with different head groups will be designed, synthesized, processed and characterized for potential application in bio- and chemical-sensors and devices. In addition, these monolayers with specific recognition sites for analytes will have reversible signal transduction properties and signal may be processed by colorimetric, electrochemical, uv-visible or fluorescence methods. As part of the education program, a multidisciplinary program with training and research opportunities will be offered to both graduate and undergraduate students.

化学系的先进材料计划将此奖项授予路易斯安那州立大学。 有了这个职业奖，教授大卫斯皮瓦克将设计，合成，加工和表征聚合物单分子膜与印迹识别和转导位点。具有不同头部基团的表面活性剂二乙炔单体将在空气-水界面处与水亚相中的蛋白质有序和定向，以在单体通过紫外辐射聚合之前为单体提供识别位点。 通过比色法、电化学法、紫外-可见光法或荧光法，聚合物单层可以直接检测到响应于分析物结合/未结合的可逆信号转导，并且这些单层可以开发成用于特定生物和化学检测的装置和传感器。PI在该部门的支持下将开发纳米科学的多学科课程，特别强调化学，生物学和工程学。 此外，一个新的高分子研究计划与教学和动手实验室课程将重新启动，并提供给研究生和本科生。 基于具有不同头部基团的聚丁二炔的单分子膜将被设计、合成、加工和表征，以在生物和化学传感器和器件中具有潜在的应用。 此外，这些具有分析物的特异性识别位点的单层将具有可逆的信号转导特性，并且可以通过比色法、电化学法、紫外-可见光法或荧光法处理信号。 作为教育计划的一部分，将为研究生和本科生提供多学科的培训和研究机会。