Novel target of amiloride analogues - picornaviral RNA polymerase

阿米洛利类似物的新靶点——小RNA病毒RNA聚合酶

• 批准号: DP0987855
• 负责人: Prof Steven Petrou
• 金额: $ 20.64万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0987855
• 关键词: Novel; target; amiloride; analogues; picornaviral

Picornaviruses cause a range of diseases such as poliomyelitis, meningitis, myocarditis, hepatitis A, neonatal sepsis and common cold. No antiviral treatment is available for these infections. Nearly 50% of antiviral drugs used in medicine are viral polymerase inhibitors; however picornaviral RNA polymerase has been largely overlooked as a drug target. We have discovered a group of compounds that inhibit picornaviral RNA polymerase. This project aims to define the inhibition mechanism and to evaluate a potential use of these compounds for antiviral drug development.

小核糖核酸病毒引起一系列疾病，如脊髓灰质炎、脑膜炎、心肌炎、甲型肝炎、新生儿败血症和普通感冒。没有抗病毒治疗可用于这些感染。近50%的抗病毒药物是病毒聚合酶抑制剂，然而小核糖核酸病毒RNA聚合酶作为药物靶点在很大程度上被忽视。我们已经发现了一组抑制小核糖核酸病毒RNA聚合酶的化合物。该项目旨在确定抑制机制，并评估这些化合物用于抗病毒药物开发的潜在用途。