Targeted therapy in genetic epilepsy

遗传性癫痫的靶向治疗

• 批准号: nhmrc : 1106035
• 负责人: Prof Steven Petrou
• 金额: $ 51.94万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeted-therapy-genetic-epilepsy/662880
• 关键词: Targeted; therapy; genetic; epilepsy

The aim of this application is to find new therapeutic strategies for genetic epilepsy. "Disease in a dish" models as well as whole animal models will be generated that contain patient gene mutations and the underlying disease processes will be characterised. Using these models a range of existing and new drugs will be tested to select those that most completely reverse these disease processes. These results will feed into clinical trials in patients with appropriate genetic profiles.

本申请的目的是为遗传性癫痫找到新的治疗策略。将产生含有患者基因突变的“盘中疾病”模型以及整个动物模型，并将表征潜在的疾病过程。使用这些模型，将测试一系列现有的和新的药物，以选择那些最完全逆转这些疾病过程的药物。这些结果将用于具有适当遗传特征的患者的临床试验。