New Multicomponent SMB/Chromatographic Separations

本计画针对二元及三元分离问题，发展数种改良的模拟移动床系统。 对3区和4区SMB系统的萃余液和萃取液流进行了选择性部分取出（仅在部分循环期间取出产品）和双产品取出（使用两条产品线生产相同产品）分析。 详细的计算机模拟用于优化流速。 在研究过程中正在设计一些新的SMB级联。 这些新的级联被设计成在使用较少或相同量的解吸剂的同时产生更好的分离。 本研究使用详细的模拟来描述二元分离问题，对于该二元分离问题，新SMB级联具有比标准4区SMB更低的解吸剂使用和/或更高的生产率，同时获得相同的产品纯度。选择最有希望的候选者进行实验确认。由于三元SMB分离变得越来越重要，特别是在制药工业中，许多新的三元SMB级联也正在研究用于三元系统的完全分离和用于其中仅需要来自三元进料的一种产物的情况。 还将分析四元进料的SMB级联。 吸附模拟器正在被引入研究生水平的化学工程课程。 模拟移动床（SMB）吸附系统已被证明是进行大规模色谱法用于二元分离的最具成本效益的方法，并且已被商业化用于许多分离，例如对二甲苯纯化、果糖和葡萄糖的分离，以及最近的光学异构体分离。 SMB系统被认为是昂贵的分离技术，其成本主要由解吸剂的使用和生产率决定。 如果成功，这项研究将最终证明，与目前的4区SMB技术相比，解吸剂的使用和生产率可以显着提高。 正在开发的用于二元分离的新级联将显著提高生产率而不增加解吸剂的使用，而正在开发的用于三元分离的新级联将显著提高生产率并减少解吸剂的使用。 这些新的设计将对用于工业分离的SMB系统的设计产生重大影响，从而对产品成本产生重大影响。

This project is developing a number of improved simulated moving-bed (SMB) systems for both binary and ternary separation problems. Selective partial withdrawal (removal of product during only part of the cycle) and dual product withdrawal (use of two product lines for the same product) are analyzed for both the raffinate and extract streams for 3 and 4-zone SMB systems. Detailed computer simulations are used to optimize flow rates. A number of additional new SMB cascades are being devised in the course of the research. These new cascades are designed to result in better separations while using less or the same amount of desorbent. This research uses detailed simulations to delineate binary separation problems for which the new SMB cascades have lower desorbent use and/or higher productivity than a standard 4-zone SMB while obtaining the same product purities. The most promising candidates are selected for experimental confirmation. Since ternary SMB separations are becoming increasingly important, particularly in the pharmaceutical industry, a number of new ternary SMB cascades are also being examined for both complete separation of the ternary system and for the case where only one product is desired from the ternary feed. SMB cascades for quaternary feeds will also be analyzed. Adsorption simulators are being introduced into graduate-level chemical-engineering courses. Simulated Moving Bed (SMB) adsorption systems have proven to be the most cost effective method for doing large-scale chromatography for binary separations and have been commercialized for a number of separations such as p-xylene purification, separation of fructose and glucose, and, most recently, optical isomer separations. SMB systems are considered to be expensive separation techniques, with costs dominated by desorbent use and productivity. If successful, this research will conclusively prove that desorbent use and productivity can be significantly improved compared to current 4-zone SMB technology. The new cascades being developed for binary separations will significantly increase the productivity without increasing desorbent use, while the new cascades being developed for ternary separations will significantly increase the productivity and decrease desorbent use. These new designs will have a significant impact on the design of SMB systems for industrial separations and hence on product cost.