Transition metals in Organic Synthesis

有机合成中的过渡金属

• 批准号: 0212388
• 负责人: Marie Krafft
• 金额: $ 42.8万
• 依托单位: Florida State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0212388&HistoricalAwards=false
• 关键词: Transition; metals; Organic; Synthesis

The use of transition metals in organic synthesis forms the rationale and unifying concept for this project. The foci of this research are threefold. First, the regioselective reactions of pi-allyl Pd complexes will be studied; second, the template-enhanced asymmetric synthesis of the natural product ophiobolin-C will be carried out and third, the asymmetric synthesis of magellanine will be accomplished using Pauson-Khand cycloaddition methodology. With this proposal, the Organic and Macromolecular Chemistry Program is supporting the research efforts of Dr. Marie E. Krafft of the Department of Chemistry at Florida State University. Professor Krafft will focus her work on developing new organometallic reactions which can be used to carry out selective carbon-carbon bond forming reactions and to apply the methodology towards the synthesis of natural properties having interesting biological properties. The work has broader impact on the pharmaceutical and agricultural industries and the project provides an excellent training ground for undergraduate, graduate and postdoctoral collaborators.

过渡金属在有机合成中的应用构成了本项目的基本原理和统一概念。 这项研究的重点有三个方面。 首先，研究了π-烯丙基钯配合物的区域选择性反应;其次，进行了天然产物蛇孢菌素-C的模板增强不对称合成;第三，采用Pauson-Khand环加成方法实现了麦哲伦碱的不对称合成。 有了这个提议，有机和高分子化学计划正在支持玛丽博士的研究工作。佛罗里达州立大学化学系的克拉夫特说。 Krafft教授将专注于开发新的有机金属反应，这些反应可用于进行选择性碳-碳键形成反应，并将该方法应用于具有有趣生物特性的天然特性的合成。 这项工作对制药和农业行业产生了更广泛的影响，该项目为本科生，研究生和博士后合作者提供了一个很好的培训基地。