Organic Reactions Using Colbalt Alkyne Complexes

使用钴炔配合物的有机反应

• 批准号: 9305491
• 负责人: Marie Krafft
• 金额: $ 55.51万
• 依托单位: Florida State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-04-01 至 1998-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9305491&HistoricalAwards=false
• 关键词: Organic; Reactions; Using; Colbalt; Alkyne

The focus of this research involves a systematic reinvestigation of the mechanism of the Pauson-Khand reaction which will give a better understanding this important process. Second, the Pauson-Khand reaction will be used as a key step in the synthesis of the natural product asteriscanolide and, third, Professor Krafft will probe electrophilic addition to unactivated alkenes. %%% With this renewal award, the Synthetic Organic Program is supporting the research of Dr. Marie E. Krafft of the Department of Chemistry at Florida State University. Professor Krafft will focus her work on the chemistry of cobalt-alkyne complexes. Both mechanistic studies and synthetic applications of the the Pauson-Khand reaction will be carried out in order to develop new strategies for the construction of carbon-carbon bonds.

本研究的重点是对Pauson-Khandd反应的机理进行系统的重新研究，这将使我们更好地理解这一重要过程。第二，Pauson-Khandd反应将被用作合成天然产物海星内酯的关键步骤，第三，克拉夫特教授将探索未活化的烯烃的亲电加成反应。%有了这一续期奖，合成有机计划将支持佛罗里达州立大学化学系的玛丽·E·克拉夫特博士的研究。克拉夫特教授将把她的工作重点放在钴-炔络合物的化学上。为了开发构建碳-碳键的新策略，将开展Pauson-Khandd反应的机理研究和合成应用。