Organic Synthesis Using Transition Metals

本研究的重点是利用含有螯合亲核试剂和与金属中心结合的杂原子的eta-3-烯丙基钼配合物开发C-C键的方法。配合物与亲电试剂反应，如醛，具有高度的区域选择性和非对映选择性。有了这个更新奖，有机和大分子化学项目支持佛罗里达州立大学化学系的玛丽·e·克拉夫特博士的研究。克拉夫特教授将把她的工作重点放在利用钼配合物与亲电试剂的反应开发C-C键形成方法上。该方法对天然产物的合成具有潜在的影响。此外，该研究为研究生和本科生提供了一个宝贵的训练基地。

The focus of this research is the development of C-C- bond making methodology using eta-3-allylmolybdenum complexes containing a chelating nucleophile and a heteroatom bound to the metal center. The complexes react with electrophiles, such as aldehydes, with a high degree of both regio and diastereoselectivity. With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Marie E. Krafft of the Department of Chemistry at Florida State University. Professor Krafft will focus her work on the development of C-C bond forming methodology using the reactions of molybdenum complexes with electrophiles. The methodology has potential impact for the synthesis of natural products. Further, the research provides a valuable training ground for both graduate and undergraduate students.