The Morita-Baylis-Hillman Reaction Revisited

重温森田-贝利斯-希尔曼反应

• 批准号: 0508969
• 负责人: Marie Krafft
• 金额: $ 42.05万
• 依托单位: Florida State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0508969&HistoricalAwards=false
• 关键词: Morita; Baylis; Hillman; Reaction; Revisited

The use of alternative electrophiles in the Morita-Baylis-Hillman (MBH) reaction, an organocatalytic three-component coupling of an enone with an aldehyde under the catalytic influence of a tertiary amine or phosphine, will be investigated. Three new reactions, using allylic halides, alkyl halides and epoxides as alternative electrophilic partners, will be studied in detail to evaluate their scope and limitations. Tandem processes linked to the MBH reaction, and the use of vinyl carbene complexes in the MBH reaction will combine to enhance the synthetic utility of the proposed research.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Marie E. Krafft of the Department of Chemistry at Florida State University. Professor Krafft and her students are developing novel methods for the construction of organic molecules through the use of reactions that unite three reactants to form a single more complex product. These multicomponent reactions are mediated by organic catalysts, obviating the need for use of metal-containing catalysts, and offer promise in the design of new synthetic strategies towards targets of synthetic and medicinal value.

将研究替代亲电子试剂在 Morita-Baylis-Hillman (MBH) 反应中的使用，该反应是在叔胺或膦的催化作用下烯酮与醛的有机催化三组分偶联。将详细研究使用烯丙基卤化物、烷基卤化物和环氧化物作为替代亲电子伴侣的三种新反应，以评估其范围和局限性。与 MBH 反应相关的串联过程以及在 MBH 反应中使用乙烯基卡宾配合物将结合起来增强拟议研究的合成效用。有机和高分子化学项目通过这一续奖来支持佛罗里达州立大学化学系 Marie E. Krafft 博士的研究。克拉夫特教授和她的学生正在开发新的方法来构建有机分子，通过使用将三种反应物结合形成一种更复杂的产物的反应。这些多组分反应由有机催化剂介导，无需使用含金属催化剂，并为设计针对合成和药用价值目标的新合成策略提供了希望。