Amine Directed, Cobalt Catalyzed Cyclizations in Organic Synthesis (Chemistry)

有机合成中的胺导向、钴催化环化（化学）

• 批准号: 8704933
• 负责人: Marie Krafft
• 金额: $ 19.55万
• 依托单位: Florida State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-06-01 至 1990-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8704933&HistoricalAwards=false
• 关键词: Amine; Directed; Cobalt; Catalyzed; Cyclizations

This grant in the Organic and Macromolecular Chemistry Program is directed towards the development of new synthetic organic methods, which will permit the preparation of new materials of biological and theoretical interest. New synthetic methodology will be developed for the regiospecific formation of carbon-carbon bonds using a cobalt-catalyzed cyclization. Regiospecificity is to be obtained by the use of a directing ligand on one of the two cyclization substrates. Specificity of the ligand directed-olefin-acetylene cyclization to form cyclopentenones has already been demonstrated. The functionality generated in an olefin- acetylene cyclization (Khand-Pauson reaction) can be utilized in a three-carbon ring expansion sequence. Potential applications of the ring expansion to problems in natural product synthesis are envisioned.

有机化学和高分子化学计划的这笔赠款用于开发新的合成有机方法，这将允许制备具有生物学和理论意义的新材料。将开发一种新的合成方法，用于使用钴催化的环化反应形成特定区域的碳-碳键。区域特异性是通过在两个环化底物中的一个上使用定向配体来获得的。配体定向烯烃-乙炔环合生成环戊酮的专一性已被证明。在烯烃-乙炔环化(Khandd-Pauson反应)中产生的官能团可用于三碳环膨胀序列。展望了环展开法在天然产物合成问题中的潜在应用。