Dynamics of Spin Polarized Free Radicals in Polymeric and Photobiological Systems

聚合物和光生物系统中自旋极化自由基的动力学

• 批准号: 0213516
• 负责人: Malcolm Forbes
• 金额: $ 46.5万
• 依托单位: University of North Carolina at Chapel Hill
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0213516&HistoricalAwards=false
• 关键词: Dynamics; Spin; Polarized; Free; Radicals

This research project deals with fundamental studies in radical pair dynamics with applications in photobiology and polymer chemistry. Professor Forbes will develop methodology for the observation and analysis of spin polarization phenomena in single amino acids, short peptides and proteins. Using a new dye sensitization reaction, he will characterize several amino acid radical cations and neutral radicals and investigate their conformational and chemical dynamics. In the polymer area, a major issue will be to determine the degree of influence of long range macromolecular motion on the locally measured dynamic effects in the time-resolved electron paramagnetic resonance (TREPR) spectra. New molecular dynamic simulations of interesting micelles will be carried at the North Carolina Supercomputing Center and new photochemically active surfactants will be synthesized to learn if control can be exerted over the starting point for diffusion of the ensuing free radicals. Further work will be done on the photochemical degradation of beer using sensitizers and visible light. This work has the potential to impact the entire multi-million dollar per year beverage industry.With this Award, the Organic and Macromolecular Chemistry Program and the Central and Eastern Europe Program in the Office of International Science and Engineering continues support for the research of Professor Malcolm D. E. Forbes of the University of North Carolina at Chapel Hill. Professor Forbes work is at the forefront of photochemical research. He is developing sophisticated magnetic resonance methods along with computer modeling to obtain valuable information on several important chemical systems.

本研究计画主要探讨自由基对动力学之基础研究，并应用于光生物学及高分子化学。福布斯教授将发展方法学，用于观察和分析单个氨基酸、短肽和蛋白质中的自旋极化现象。使用一种新的染料敏化反应，他将表征几种氨基酸自由基阳离子和中性自由基，并研究它们的构象和化学动力学。在聚合物领域，一个主要的问题将是确定大分子的长程运动的影响程度上的局部测量的动态效应的时间分辨电子顺磁共振（TREPR）光谱。将在北卡罗来纳州超级计算中心对感兴趣的胶束进行新的分子动力学模拟，并将合成新的光化学活性表面活性剂，以了解是否可以对随后的自由基扩散的起始点进行控制。进一步的工作将做啤酒的光化学降解使用敏化剂和可见光。这项工作有可能影响到整个数百万美元的饮料行业每年。有了这个奖项，有机和高分子化学计划和中欧和东欧计划在国际科学与工程办公室继续支持教授马尔科姆D。E.查佩尔山的北卡罗来纳州大学的福布斯说。 福布斯教授的工作处于光化学研究的前沿。他正在开发复杂的磁共振方法，沿着计算机建模，以获得几个重要化学系统的有价值的信息。