SBIR/Phase I: New Methods for Detecting Bioterrorism

SBIR/第一阶段：检测生物恐怖主义的新方法

• 批准号: 0214853
• 负责人: Andrzej Drukier
• 金额: $ 10万
• 依托单位: BioTraces Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0214853&HistoricalAwards=false
• 关键词: SBIR; Phase; New; Methods; Detecting

0214853DrukierThis Small Business Innovation Research Phase I project proposes to examine Multi Photon Detection (MPD) of biological warfare agents using a panel of MPD enhanced immunoassays. MPD based techniques promise to deliver: (1) parallel detection of all biological warfare agents, (2) improved sensitivity of biotoxin detection, leading to fewer false positives and negatives, (3) more rapid results, (4) lower cost per assay, and (5) greater ease of use. This Phase I project has the following specific objectives : (1) production of recombinant fragments of biotoxins and development of antibodies, (2) development and characterization of antibodies for biotoxins, including botulism, tetanus and anthrax, (3) development of IA/MPD (MPD enhanced immunoassay) for these three biotoxins and comparison of sensitivity with the prior art, mainly ELISA, and (4) further assay optimization.The commercial application of this project is in the area of homeland security.

这个小企业创新研究第一阶段项目建议使用一组多光子检测增强的免疫分析来检查生物战剂的多光子检测(MPD)。基于MPD的技术有望提供：(1)所有生物战剂的并行检测，(2)提高生物毒素检测的灵敏度，导致更少的假阳性和假阴性，(3)更快的结果，(4)更低的每次检测成本，以及(5)更容易使用。这一阶段的项目有以下具体目标：(1)生物毒素重组片段的生产和抗体的开发，(2)肉毒杆菌、破伤风和炭疽等生物毒素抗体的开发和鉴定，(3)这三种生物毒素的IA/MPD(MPD增强型免疫分析)的发展及其与现有技术(主要是ELISA)的敏感性比较，以及(4)进一步的检测优化。