Multilabel Imager for Genomics

用于基因组学的多标签成像仪

• 批准号: 9261457
• 负责人: Andrzej Drukier
• 金额: $ 4.99万
• 依托单位: BioTraces Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-01-01 至 1993-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9261457&HistoricalAwards=false
• 关键词: Multilabel; Imager; Genomics

BioTraces Inc. (BT Inc.) has developed an ultrasensitive quantitation system which can be used with a large family of isotopes. This system supports label multiplexing; many co- resident isotopes in the family can be quantitated simultaneously, allowing either the pooling of labeled samples of the pooling of distinctly labeled probe reagents for multiple targets. The proposed research will add two dimensional (2D) spatial resolution to the capabilities of the systems, in support of nucleic acid quantitation and fractionation, including sequencing. Because of the extensive multiplexing capabilities and superior sensitivity, the proposed technique will greatly increase sample throughput in fractionation/quantitation tasks.

BioTraces公司(BT Inc.)已经开发出一种超灵敏的定量系统，可以与一大类同位素一起使用。该系统支持标记多路复用；可以同时定量该家族中的许多共存的同位素，允许将标记的样品汇集在一起，或者将不同标记的探针试剂汇集在一起用于多个靶标。拟议的研究将在系统能力的基础上增加二维(2D)空间分辨率，以支持核酸定量和分级，包括测序。由于广泛的多路复用能力和卓越的灵敏度，该技术将极大地提高分馏/定量任务中的样品吞吐量。