Acquisition of a High-Resolution Scanning Transmission Electron Microscope for Interdisciplinary Nanoscience Research

购买高分辨率扫描透射电子显微镜用于跨学科纳米科学研究

• 批准号: 0216492
• 负责人: Norbert Scherer
• 金额: $ 80万
• 依托单位: University of Chicago
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0216492&HistoricalAwards=false
• 关键词: Acquisition; Resolution; Scanning; Transmission; Electron

With support from the Major Research Instrumentation (MRI) Program, Norbert F. Scherer and colleagues at the University of Chicago will acquire a high-resolution scanning transmission electron microscope (S/TEM) for interdisciplinary nanoscience research. The STEM will be used to study systems in nano-physics, nano-chemistry, and nano-biology. Some of the applications include characterization of nanocrystals; diblock copolymer used for making nanoparticle array wires; phase separation and structure studies for electroactive diblock copolymers; hemoglobin fiber formation and sickle cell anemia; genome-scale genetic analysis and fabrication of nano-structured materials with novel properties; biomembranes; high resolution e-beam writing using photoresists; and new direct methods of pattern formation. Much of the research at the forefront of structural and cell biology and nanoscience requires routine characterization of specimens by a combination of transmission electron microscopy (TEM) and scanning transmission electron microscopy (S/TEM). High-end TEM is unsurpassed in terms of image resolution and ease of interpretation. In addition, with new capabilities such as tomography, electron microscopy is entering a new era in which its application can visualize molecular structure with (near-) atomic resolution.

在主要研究仪器（MRI）计划的支持下，Norbert F。芝加哥大学的谢勒及其同事将获得一台高分辨率扫描透射电子显微镜（S/TEM），用于跨学科的纳米科学研究。 STEM将用于研究纳米物理学、纳米化学和纳米生物学系统。 一些应用包括纳米晶体的表征;用于制造纳米颗粒阵列线的二嵌段共聚物;电活性二嵌段共聚物的相分离和结构研究;血红蛋白纤维形成和镰状细胞贫血症;基因组规模的遗传分析和具有新特性的纳米结构材料的制造;生物膜;使用光致抗蚀剂的高分辨率电子束写入;和新的图案形成的直接方法。 结构和细胞生物学以及纳米科学前沿的许多研究需要通过透射电子显微镜（TEM）和扫描透射电子显微镜（S/TEM）的组合对样本进行常规表征。 高端TEM在图像分辨率和易于解释方面无与伦比。 此外，随着断层扫描等新功能的出现，电子显微镜正在进入一个新时代，其应用可以以（近）原子分辨率可视化分子结构。