CRCNS: Modeling Pathfinding and Target Recognition in the Olfactory System

[参考译文]lin， DavidCornell university - statecrns：嗅觉系统的寻路和目标识别建模供公众使用的声明神经系统的正常发育对任何生物体的功能都是必不可少的。神经系统整合感觉输入，协调运动输出，控制自主神经功能，塑造记忆和认知。为了完成这些任务，神经系统使用了数十亿个神经元，这些神经元将与相应的目标形成数万亿个连接。例如，在嗅觉系统中，环境中的气味是由位于鼻子中的嗅觉感觉神经元（OSNs）检测到的。然而，为了将气味信息正确地传递到大脑，这些神经元必须与大脑中相应的伙伴连接起来，或者“连接在一起”。寻径和目标识别这一关键壮举是如何完成的，在很大程度上仍然未知。在一个模型中，这个过程是由位于大脑内不同点的线索介导的，这些线索会与神经元相互作用并引导神经元到达目标。从本质上讲，这些线索会形成一个“路线图”，帮助神经元到达它们的目标。在这个提议中，我们将结合生物信息学、统计方法和基因组学来开始确定这张地图的形状。作为一个模型系统，我们将研究嗅觉感觉神经元（OSNs）在嗅球中识别其目标的能力。

EIA-0218521Lin, DavidCornell University-StateCRCNS: Modeling Pathfinding and Target Recognition in the Olfactory SystemStatement for public consumptionThe proper development of the nervous system is essential to the f unction of any organism. The nervous system integrates sensory input, coordinates motor output, controls autonomic functions, and shapes memory and cognition. To accomplish these tasks, the nervous system employs billions of neurons that will form trillions of connections with their appropriate targets. For example, in the olfactory system, odorant in the environment are detected by olfactory sensory neurons (OSNs) located in the nose. In order for odorant information to be properly transmitted to the brain, however, these neurons must be connected, or "wired together," with their appropriate partners in the brain. How this critical feat of pathfinding and target recognition is accomplished is still largely unknown. In one model, this process is mediated b cues located at various points within the brain that would interact with and guide neurons to their target. These cues would form, in essence, a "roadmap", that would help guide neurons to their target.In this proposal, we will combine bioinformatics, statistical methods, and genomics to begin to determine the shape of this map. As a model system, we will study the ability of olfactory sensory neurons (OSNs) to identify their targets in the olfactory bulb.