Upgrade of a Scanning Probe Microscope for Chemical and Biochemical Analysis
Upgrade of a Scanning Probe Microscope for Chemical and Biochemical Analysis
批准号:
0225622
负责人:
Shaoyi Jiang
金额:
$4.0万
依托单位:
依托单位国家:
美国
项目类别:
Standard Grant
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-08-01 至 2003-07-31
中文摘要
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英文摘要
Shaoyi Jiang, University of Washington"Upgrade of a Scanning Probe Microscope for Chemical and Biochemical Analysis"The scanning probe microscopic (SPM) technique can be used not only for the characterization of surfaces at the sub-nanometer resolution, but also for the measurement of nano-scale forces. SPM has been one of main techniques used in the PI's group for various ongoing nanotechnology projects, including (a) characterizing self-assembled monolayers (SAMs) formed by alkanethiols on Au(111), dendrimer monolayers on Au(111), and alkyl monolayers on Si(111) at the molecular resolution, (b) studying protein adsorption and detecting antigen-antibody interactions, and (c) measuring quantitative frictional properties of various thin films. Tapping mode SPM is very important for these ongoing projects, particularly for the study of interfacial phenomena and properties of biological systems on surfaces in liquids. The current SPM system in the PI's group was acquired from Digital Instruments (DI) about five years ago. It has been heavily used in various research and teaching activities. However, it does not have many important features, such as tapping mode operation. The PI proposes to upgrade the existing SPM from NanoScope E to NanoScope IIIa Control Station with Extender Electronics Module. This upgrade will allow the PI's group to perform tapping mode SPM in liquids. Upgrade of the SPM will greatly enhance the PI's research capacities, broaden his research areas, and facilitate collaborations with people on and off campus. The broader impact of this grant will be that many graduate students and undergraduate students will benefit from the instrument through their research experience or laboratory sessions in a course. If the research is successful, society will benefit through better biocompatible materials.
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Hydrolysable Zwitterionic-Based Biomaterials for Effective Gene Delivery
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Ultra-low Fouling Peptide-Based Thin Films, Nanoparticles, and Polymers
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Molecular Engineering of Low Friction and Biocompatible Surfaces
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SGER: Superlow Fouling Materials Inspired by Naturally Occurring Zwitterions
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Dual-Functional Zwitterionic Biomaterials for Targeted Drug Delivery
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Molecular Design of Nonfouling and Smart Materials
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Protein Interactions with Nano-Scale Controlled Surfaces: The Molecular Basis for Non-fouling Behavior
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Sensors: A Novel Protein Immobilization Technique for Protein Array Sensors with High Stability, Multiple Functionalities, and Excellent Sensitivity
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Hybrid Molecular Simulation Studies of Nano-Scale Adhesion and Friction: Chemical Termination and Solvent Effects
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CAREER: Exploring Nano-Scale Properties of Functionalized Monolayers: An Integrated Molecular Simulation and Experimental Study
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财政年份:2001
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海外基金