Engineered Polymer Nanoparticles: A Potent Weapon Against Cancer

工程聚合物纳米粒子：抗癌的有力武器

• 批准号: DP0985215
• 负责人: Prof Michael Monteiro
• 金额: $ 27.72万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0985215
• 关键词: Engineered; Polymer; Nanoparticles; Potent; Weapon

Cervical cancer is the commonest cause of cancer death in women under the age of 50 worldwide, the 8th most common cancer among women in Australia, and is the leading cause of cancer death in Aboriginal women. While a vaccine is available to prevent HPV-mediated disease, it would not impact upon death rates for at least 25 years. The systemic delivery of RNAi offers to best opportunity to solve this problem. The delivery devices will be designed with precision and function to meet the delivery needs in vivo. These polymer structures will be suitable for use in drug and gene delivery providing Australian products with advanced features and capabilities, significantly improving product performance.

宫颈癌是全世界50岁以下妇女癌症死亡的最常见原因，是澳大利亚妇女第8大常见癌症，也是土著妇女癌症死亡的主要原因。虽然有一种疫苗可以预防HPV介导的疾病，但它至少在25年内不会影响死亡率。RNAi的系统性递送为解决这一问题提供了最好的机会。输送器械的设计精度和功能将满足体内输送需求。这些聚合物结构将适用于药物和基因递送，为澳大利亚产品提供先进的功能和能力，显着提高产品性能。