CAREER: Theoretical Investigations of Non-Equlibrium Processes in Chemistry and Biology

职业：化学和生物学中非平衡过程的理论研究

• 批准号: 0237105
• 负责人: Anatoly Kolomeisky
• 金额: $ 46.5万
• 依托单位: William Marsh Rice University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0237105&HistoricalAwards=false
• 关键词: CAREER; Theoretical; Investigations; Non; Equlibrium

Anatoly Kolomeisky of Rice University is supported by the Theoretical and Computational Chemistry Program to pursue research and disseminate knowledge in the area of non-equilibrium processes relevant to a microscopic chemistry-based understanding of biology. He will study the dynamics of polymer translocation across nanopores, extend models to explain why the ligand-receptor bond rupture as a function of loading rate deviates from Hooke's law, investigate molecular motors, and determine the mechanisms for polymerization in biologically interesting filaments. This field lies at the interface of chemistry, physics and biology and the research will be closely coupled to the training of undergraduate, graduate and postdoctoral students.The underlying role of physical chemistry in biology remains an intellectually challenging problem area of great relevance to future biochemical technologies. Problems addressed in this proposal will allow for a better understanding of targeted delivery of pharmaceuticals and subsequent dispersal. A related area in need of a microscopic understanding is how conversion of energy into motion proceeds in biological systems. Examples of such processes, all of which are facilitated by molecular motors, include cell division and transport, molecular contraction and genetic transcription. Kolomeisky plans to extend his research on molecular motors. Imparting the knowledge and requisite skills to a multidisciplinary array of chemical, biological and physical scientists will be accomplished by introducing a course on biophysical chemistry that is aimed at the advanced undergraduate or beginning graduate level student. Early interest in this new area will be raised by outreach to high school students and teachers.

莱斯大学的Anatoly Kolomeisky得到了理论和计算化学计划的支持，致力于研究和传播与基于微观化学的生物学理解相关的非平衡过程领域的知识。他将研究聚合物跨纳米孔转移的动力学，扩展模型以解释为什么配体-受体键断裂作为负载率的函数偏离胡克定律，研究分子马达，并确定具有生物学意义的细丝中的聚合机制。该领域位于化学、物理和生物学的交界处，这项研究将与本科生、研究生和博士后的培养密切结合。物理化学在生物学中的潜在作用仍然是一个具有智力挑战性的问题领域，与未来的生化技术密切相关。这项提案中涉及的问题将使人们能够更好地了解药物的定向运送和随后的散布。一个需要微观理解的相关领域是如何在生物系统中将能量转化为运动。这种过程的例子包括细胞分裂和运输、分子收缩和基因转录，所有这些过程都由分子马达促进。科洛梅斯基计划扩大他对分子马达的研究。向多学科的化学、生物和物理科学家传授知识和必要的技能，将通过开设一门针对高级本科生或初级研究生的生物物理化学课程来完成。这一新领域的早期兴趣将通过与高中生和教师的接触来提高。