CAREER: Biomolecular Nanoelectronic Junctions

职业：生物分子纳米电子结

• 批准号: 0239333
• 负责人: Luke Lee
• 金额: $ 40万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0239333&HistoricalAwards=false
• 关键词: CAREER; Biomolecular; Nanoelectronic; Junctions

The objective of this CAREER project is to establish a significant advancement in biomolecular nanoelectronics by theoretical modeling and interfacing liquid-state biopolymers to solid-state nanoelectronic devices. The scientific component of this project aimed on the theoretical modeling of dielectric behavior of biopolymers and elucidating experimentally interactions of DNA-counterion, RNA-DNA, protein-protein, and actin filament-counterion in the cavity between two nanogap electrodes. The technological components of this project focus on the precise control of sub10 nm nanogap electrode for biosensors, development of sensitive label free bioassays, and a robust batch fabrication method of integrated nanogap electrode arrays with nanofluidic networks. The educational goal of this project is to effectively integrate research into educational activities and the training of both undergraduate and graduate students in interdisciplinary studies: Special educational outreach program will be accomplished through summer research training camp to educate women and under-represented students in junior and senior high school. Overall educational goal is to train students how to carry out their research with sound theory and hand on laboratory skill for their advanced careers in quantitative biological sciences or biophysical engineering.

这个CAREER项目的目标是通过理论建模和将液态生物聚合物连接到固态纳米电子器件来建立生物分子纳米电子学的重大进展。该项目的科学组成部分旨在对生物聚合物的介电行为进行理论建模，并通过实验阐明两个纳米间隙电极之间的空腔中DNA-补体、RNA-DNA、蛋白质-蛋白质和肌动蛋白-补体的相互作用。该项目的技术组成部分集中在生物传感器的sub10 nm纳米间隙电极的精确控制，灵敏的无标记生物测定的开发，以及集成纳米间隙电极阵列与纳米流体网络的稳健批量制造方法。该项目的教育目标是有效地将研究纳入教育活动，并在跨学科研究中培训本科生和研究生：将通过夏季研究训练营完成特别教育推广方案，以教育初中和高中的妇女和代表性不足的学生。总体教育目标是培养学生如何用健全的理论和实验室技能进行研究，为他们在定量生物科学或生物物理工程的高级职业生涯。