Towards more realistic host-parasite models

建立更真实的宿主-寄生虫模型

• 批准号: 0314575
• 负责人: Zhilan Feng
• 金额: $ 38.9万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-15 至 2007-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0314575&HistoricalAwards=false
• 关键词: Towards; more; realistic; host; parasite

Feng, Milner, Minchella The interactions between parasitic trematodes and theirinvertebrate and vertebrate hosts are complex. Models of theseinteracting systems are similarly complex in order to capturebiologically relevant features of the systems. Advances for manyquestions in this area face difficulties in part because of thelarge number of parameters involved in the models and because ofthe limited data available. The investigators combine thetheoretical and empirical experience of a parasitologist and themodeling and theoretical expertise of mathematicians to developand investigate these models. The work of this project isthreefold: first, new models are proposed for host-parasiteinteractions, with more complex models motivated by biologicalconsiderations and newly available data; second, a study of somemathematical properties of each model is carried out and theirbiological and ecological implications assessed, such as parasitepopulation control or potential species extinction; third,validation of the models through comparison of model results withfield data follows. The goal of the project is to develop a theoreticalframework for the study of questions associated withhost-parasite interactions. A particular host-parasite system isused, human-schistosome-snail (macroparasitic disease), tohighlight the generality of our approach. Specific objectives areto develop mathematical models to understand the role of variouscomponents of host-parasite interactions in the diseasetransmission dynamics, to determine which biological details arecritical components in the model, to construct and analyzeappropriate models in which the parameters are readily related tofield data, and to provide useful information for field workersand policy makers in public health. The project significantlyadvances our knowledge and understanding of the dynamics ofhost-parasite systems that include intermediate hosts, byproviding usable models to study natural systems, by analyzingtheir sensitivity to the parameters affecting the dynamics, andby allowing structuring of the complexities of the systems intohierarchies. Just as important is the possibility to help addresssome of the theoretical issues in the control of schistosomiasisvia chemotherapy.

冯，米尔纳，明切拉 寄生吸虫与其无脊椎动物和脊椎动物宿主之间的相互作用是复杂的。 这些相互作用系统的模型同样复杂，以捕捉系统的生物相关功能。 这一领域许多问题的进展面临困难，部分原因是模型中涉及的参数数量太多，而且可用的数据有限。 研究人员将寄生虫学家的理论和经验经验与数学家的建模和理论专业知识结合起来，联合收割机来开发和研究这些模型。 该项目的工作有三个方面：第一，提出了宿主-寄生虫相互作用的新模型，其中更复杂的模型是基于生物学考虑和新获得的数据;第二，对每个模型的一些数学性质进行研究，并评估其生物学和生态学意义，如寄生虫种群控制或潜在的物种灭绝;第三，通过将模型结果与现场数据进行比较来验证模型。 该项目的目标是为研究与宿主-寄生虫相互作用有关的问题建立一个理论框架。 一个特殊的主机寄生虫系统，人类寄生虫蜗牛（巨寄生虫病），突出我们的方法的一般性。 具体目标是建立数学模型，以了解宿主-寄生虫相互作用的各个组成部分在疾病传播动力学中的作用，确定模型中哪些生物学细节是关键组成部分，构建和分析适当的模型，其中参数与现场数据托菲尔德相关，并为现场工作者和公共卫生决策者提供有用的信息。 该项目通过提供研究自然系统的可用模型，通过分析它们对影响动态的参数的敏感性，以及通过允许将系统的复杂性结构化为层次结构，显著地推进了我们对包括中间宿主的宿主-寄生虫系统的动态的知识和理解。 同样重要的是，它有可能帮助解决通过化疗控制子宫肌瘤的一些理论问题。