Workshop: The influence of cooperative bacteria on animal host biology

研讨会：合作细菌对动物宿主生物学的影响

• 批准号: 0314543
• 负责人: Edward Ruby
• 金额: $ 1.84万
• 依托单位: University of Hawaii
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-15 至 2004-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0314543&HistoricalAwards=false
• 关键词: Workshop; influence; cooperative; bacteria; animal

Workshop: The influence of cooperative bacteria on animal host biologyEdward G. Ruby and Margaret J. McFall-NgaiUniversity of Hawaii, ManoaThe aim of the workshop is to bring together an international group of biologists from a variety of disciplines to consider (i) the extent to which cooperative bacteria influence the biology of animals, and (ii) the mechanisms that underlie the complex beneficial relationships that occur between animal hosts and their native microbiota. The rigorous study of animal-bacterial interactions is a technology-enabled area, the advance of which relies in large part on the application of recently developed molecular tools. With high throughput sequencing, microarray technology, and direct and indirect methods of examining the genetics of the host and symbiont, we can now approach the study of the persistent, cooperative relationships that animals form with microbial communities. Because of the biomedical bias that stresses the importance of pathogenic bacterial associations with animals, biologists know much more about these unusual conditions than they do about the ubiquitous state of beneficial bacterial colonization. Not surprisingly, this focus has clouded our ability to recognize and characterize how bacteria have influenced the normal biology of their hosts.This 5-day workshop-conference will consist of individual presentations and group discussions concerning frontiers in the study of cooperative bacterial associations. The workshop will specifically focus on the roles such associations play in the evolution, ecology, and biochemical interactions of the host and its microbial symbionts. The participants will target specific fields for discussion, look for ways to increase collaborative investigations between these different fields of inquiry, and arrive at recommendations for the further development of this emerging discipline.The participants will also discuss specific outreach projects that will introduce the importance of beneficial bacterial associations to other biologists, students and the general public. The conclusions reached at the workshop will be disseminated to the scientific community through the publication by Cambridge University Press of a book that covers both the scientific proceedings and their broader implications. This volume is specifically devoted to summarizing the present state of our understanding, and the future directions that integrated research should take. Together these activities will contribute to raising the awareness of the current generation of undergraduate, graduate and medical students, as well as the general public, about the vital role played in animal biology by beneficial bacteria interactions.

合作细菌对动物宿主生物学的影响。Ruby和Margaret J. McFall-Ngai夏威夷大学，马诺研讨会的目的是汇集来自不同学科的国际生物学家小组，考虑（i）合作细菌影响动物生物学的程度，以及（ii）动物宿主与其原生微生物群之间复杂的有益关系的基础机制。动物-细菌相互作用的严格研究是一个技术支持的领域，其进展在很大程度上依赖于最近开发的分子工具的应用。 随着高通量测序，微阵列技术，以及直接和间接的方法来检查宿主和共生体的遗传学，我们现在可以接近动物与微生物群落形成的持久合作关系的研究。 由于生物医学的偏见，强调致病细菌与动物的关联的重要性，生物学家对这些不寻常的情况比他们对有益细菌定植的普遍状态了解得更多。 毫不奇怪，这一焦点已经模糊了我们识别和表征细菌如何影响宿主正常生物学的能力。这个为期5天的研讨会将包括关于合作细菌协会研究前沿的个人演讲和小组讨论。该研讨会将特别关注这些协会在宿主及其微生物共生体的进化，生态学和生化相互作用中发挥的作用。 与会者将针对特定领域进行讨论，寻找增加这些不同研究领域之间合作研究的方法，并为这一新兴学科的进一步发展提出建议。与会者还将讨论具体的外展项目，向其他生物学家，学生和公众介绍有益细菌协会的重要性。 讲习班得出的结论将通过剑桥大学出版社出版一本涵盖科学会议及其更广泛影响的书向科学界传播。 这卷是专门致力于总结我们的理解的现状，和未来的方向，综合研究应该采取。 这些活动将有助于提高当代本科生，研究生和医学生以及公众对有益细菌相互作用在动物生物学中发挥的重要作用的认识。