Selective Extraction into Nonvolatile Media

匹兹堡大学的斯蒂芬·韦伯教授得到了分析和表面化学计划的支持，该计划研究使用含氟材料从液体混合物中选择性地提取天然产品和杂质。碳氟化合物液体表现出“选择性”的溶剂化性能，聚四氟乙烯薄膜坚固耐用。具有这两个优点的新系统将被开发出来。这项工作的目标是开发以多孔氧化铝为底物的含有特定受体的氟提取介质。其逻辑是，如果周围环境对分析物来说不是很好的溶剂，那么给定的分析物的人工受体将有更好的机会诱导良好的提取选择性。该项目需要开发方法的基础工作，以创建稳定的流体氟介质，合成和筛选潜在受体分子库，并制备用于传感和提取的新型修饰电极表面。这项工作的影响在于材料化学、化学合成、分离、识别和传感器开发。在实际分析中，选择性萃取是最有效的分析物浓缩和干扰消除方法之一。在尺寸稳定的非挥发性介质(如膜和改性表面)中的选择性萃取通常是化学传感器和传感系统中的关键元件。如果能够扩大选择性萃取的规模，它可能在环境友好地回收天然物质和简单地去除杂质方面具有工业意义。

Professor Stephen Weber of the University of Pittsburgh is supported by the Analytical and Surface Chemistry Program to study selective extraction of natural products and impurities from liquid mixtures using fluorinated materials. Fluorocarbon liquids display 'selective' solvating properties and teflon membranes are robust. Novel systems possessing both advantages will be developed. The work targets the development of fluorous extraction media containing specific receptors coated onto porous alumina as substrate. The logic is that a given artificial receptor for the analyte will have a much better chance to induce a good extraction selectivity if the surrounding is a poor solvent for that analyte. This project entails the basic work of developing methods for the creation of stable, fluid fluorous media, synthesizing and screening a library of potential receptor molecules, and preparing novel modified electrode surfaces for sensing and extraction. This impact of this work lies in materials chemistry, chemical synthesis, separation, recognition, and sensor development. Selective extraction is one of the most efficient methods for analyte enrichment and for elimination of interferences in practical analysis. Selective extraction in a dimensionally-stable, non-volatile media (e.g., membranes, and modified surfaces) is often the key element in chemical sensors and sensing systems. If selective extraction can be scaled up, it may gain industrial significance in environmentally friendly recovery of natural substances and simple removal of impurities.