Potentiometric Sensors and Extraction Media for Carboxylates

电位传感器和羧酸盐萃取介质

• 批准号: 9403450
• 负责人: Stephen Weber
• 金额: $ 27.32万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-06-15 至 1997-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9403450&HistoricalAwards=false
• 关键词: Potentiometric; Sensors; Extraction; Media; Carboxylates

This grant in the Analytical and Surface Chemistry Program provides support for Professor Weber's investigations of the fundamental issues and problems associated with the development of useful membrane sensors for organic anions and the development of microextraction devices for these anions. Potentiometric sensors for cations have been successfully implemented for a variety of species, and the results have had a dramatic impact in the fields of bioanalytical chemistry and biotechnology. Professor Weber proposes to create new sensors for anionic species by synthesizing new artificial receptors for the selective extraction of anions into plasticized polymer media. New anion sensors for ions such as carboxylates, glutamate and aspartate are urgently needed in such diverse areas as neurochemistry, the food industry and biotechnology. This grant in the Analytical and Surface Chemistry Program will support research into the development of practical membrane sensors for organic anions. The goal is to create a suite of anion sensors similar in function to those already existing for cationic species. The research will involve the synthesis and characterization of artificial receptors which will selectively extract anions into polymeric membranes. The sensors will be used to detect anions such as acidic neurotransmitters, decomposition products in food, and waste products in bioreactors

分析和表面化学计划的这项资助提供了 支持韦伯教授对基本问题的研究 以及与开发有用的膜传感器相关的问题 和发展微萃取装置， 这些阴离子。 阳离子电位传感器已成功研制 对各种物种实施，结果有了戏剧性的变化。 在生物分析化学和生物技术领域的影响。 Weber教授提议通过以下方式为阴离子物种创建新的传感器： 合成新的人工受体， 阴离子进入增塑聚合物介质。 新型阴离子传感器， 由于在这些应用中迫切需要羧酸盐、谷氨酸盐和天冬氨酸盐， 神经化学、食品工业和生物技术等不同领域。 分析和表面化学计划的这笔赠款将支持 实用有机膜传感器的开发研究 阴离子。 我们的目标是创造一套类似于 对于那些已经存在的阳离子物种的功能。 研究 将涉及人工受体的合成和表征 其将选择性地将阴离子萃取到聚合物膜中。 的 传感器将用于检测阴离子如酸性神经递质， 食物中的分解产物和生物反应器中的废物