Selective Extraction with Molecular Recognition in Fluorous Media

含氟介质中分子识别的选择性萃取

• 批准号: 0078520
• 负责人: Stephen Weber
• 金额: $ 37.19万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2004-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0078520&HistoricalAwards=false
• 关键词: Selective; Extraction; Molecular; Recognition; Fluorous

This project, sponsored by the Analytical and Surface Chemistry Program, develops materials and methods for chemically selective extraction without the need for volatile solvents. The research, conducted by Dr.Stephen G. Weber and his students at the University of Pittsburgh, develops novel fluorous membranes and films on which a fluoropolymer supports a fluorous nonvolatile solvent. Membranes are prepared from Teflon (TM) AF2400, and five plasticizers to form the supported fluorous phases. These supported phases are doped with molecular recognition receptors that allow the fluorous phases to be highly selective for extraction of various target species. Partitioning experiments and infrared spectroscopic measurements are used to quantitate the influence of a particular functional group on partitioning into the fluorous phase. The results of these experiments are used to guide the design of artificial receptors and to develop libraries of receptors. The results from this project could have far ranging effects when fully utilized. Potential applications include improved chemical analysis for pharmaceuticals, reduced energy comsumption in some industries, and a reduction in waste from sample processing in analytical laboratories.

该项目由分析和表面化学项目资助，开发不需要挥发性溶剂的化学选择性提取材料和方法。这项研究是由匹兹堡大学的stephen G. Weber博士和他的学生进行的，他们开发了一种新型的含氟膜和薄膜，在这种膜上，含氟聚合物支撑着一种不挥发的含氟溶剂。膜由特氟龙（TM） AF2400和五种增塑剂制备，形成支撑的氟相。这些支持相掺杂了分子识别受体，使含氟相对提取各种目标物种具有高度选择性。分配实验和红外光谱测量被用来量化一个特定的官能团对分配到氟相的影响。这些实验结果可用于指导人工受体的设计和受体文库的建立。这个项目的成果如果得到充分利用，将产生深远的影响。潜在的应用包括改进药物的化学分析，减少某些工业的能源消耗，以及减少分析实验室样品处理的浪费。