Engineering Research Equipment: Ultrafast Laser System for Microscale Radiation Transport Studies

一个飞秒钛蓝宝石激光系统的采购合同已经签订。该设备将用于支持解决新兴纳米技术和生物成像应用的创新研究。具体来说，所要求的设备对于提出的实验是必要的，这些实验包括开发用于无创检测小乳腺肿瘤的具有时间对数斜率分析的地下成像方法，用于研究皮肤中药物传递和氧化应激的双光子荧光显微镜系统，以及用于时间分辨检测纳米级实体在表面的吸附或附着的纳米级传感系统。地下成像方法新颖，不需要复杂的反设计。该研究旨在实现漫射光学断层扫描的实时临床应用。拟议研究的广泛影响包括推动罗格斯大学的跨学科研究，以及PI在包括生物技术在内的几个新兴领域的能力发展。激光系统将加强与贝尔实验室建立的合作安排。该设备也将非常有用的训练研究生的操作和应用的最先进的超快激光系统，并介绍本科生跨学科的研究课题。它也是罗格斯大学研究基础设施的宝贵补充。

An award has been made toward the purchase of a femtosecond Ti:sapphire laser system. The equipment will be utilized in support of innovative research addressing emerging nanotechnology and bioimaging applications. Specifically, the requested equipment is necessary for the proposed experiments in developing a subsurface imaging method with temporal log-slope analysis for noninvasive detection of small breast tumors, a two-photon fluorescence microscopy system for investigation of drug delivery and oxidative stress in skins, and a nanoscale sensing system for time-resolved detection of adsorption or attachment of nanoscopic entities to a surface. The subsurface imaging method is original and does not require complicated inverse design. The study is aimed at enabling real time clinical use of diffuse optical tomography. The broad impacts of the proposed research include a boost to interdisciplinary research at Rutgers and the development of capabilities of the PI in several emerging areas, including biotechnology. The laser system will enhance a collaborative arrangement that has been established with Bell Labs. The equipment will also be very useful for the training of graduate students in the operation and applications of state-of-the-art ultrafast laser systems, and for introducing undergraduate students to interdisciplinary topics of research. It is also a valuable addition to the research infrastructure at Rutgers University.