SBIR Phase I: Mid-Infrared Diode Laser Sensor for Pharmaceutical Manufacturing

SBIR 第一阶段：用于制药制造的中红外二极管激光传感器

• 批准号: 0319202
• 负责人: William Kessler
• 金额: $ 10万
• 依托单位: Physical Sciences Incorporated (PSI)
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0319202&HistoricalAwards=false
• 关键词: SBIR; Phase; Mid; Infrared; Diode

This Small Business Innovative Research Phase I project addresses an immediate need for a real-time means of endpoint monitoring solvent drying processes in pharmaceutical manufacturing. The specific innovation is the combination of a novel, broadly tunable, mid-infrared diode laser source with ultra-sensitive absorption techniques, to provide a non-contact means for sensing trace organic solvent vapor concentrations in fluidized bed dryers and spray coaters. The probe laser source utilizes Difference Frequency Generation (DFG) to convert visible and near-infrared laser light to the mid-infrared. Its ability to continuously tune over 200 cm-1 enables the measurement of organic vapors having broad, infrared absorption bands near 3.5 microns. The Phase I objectives are to use the DFG source to measure organic solvent vapors, determine analyzer detection limits, and create a preliminary design for an industrial sensor. The Phase I program will verify the technical and commercial feasibility of the mid-infrared solvent monitor. The proposed solvent drying endpoint monitors will provide the pharmaceutical industry with real-time data enabling improved drug manufacturing process efficiency and quality. The sensors may eliminate the need for off-line residual solvent analysis that often halts processing and holds completed product for release. There are numerous applications for the technology, including environmental monitoring of organic pollutants, industrial HVAC controls, breath analysis, hospital air and gas quality control and sensors to screen for alcohol and other toxics.

这个小型企业创新研究第一阶段项目解决了制药生产中对终点监测溶剂干燥过程的实时方法的迫切需求。 具体的创新是一种新型的，广泛可调，中红外二极管激光源与超灵敏吸收技术的结合，提供了一种非接触的手段，用于感测微量有机溶剂蒸气浓度在流化床干燥器和喷涂机。探测激光源利用差频产生（DFG）将可见光和近红外激光转换为中红外激光。 其连续调谐超过200 cm-1的能力使其能够测量具有近3.5微米宽红外吸收带的有机蒸气。第一阶段的目标是使用DFG源来测量有机溶剂蒸气，确定分析仪的检测限，并为工业传感器创建初步设计。第一阶段计划将验证中红外溶剂监测仪的技术和商业可行性。拟议的溶剂干燥终点监测器将为制药行业提供实时数据，从而提高药物生产工艺的效率和质量。传感器可以消除对离线残留溶剂分析的需要，离线残留溶剂分析通常停止处理并保持完成的产品以供释放。 该技术有许多应用，包括有机污染物的环境监测，工业HVAC控制，呼吸分析，医院空气和气体质量控制以及用于筛选酒精和其他有毒物质的传感器。