SBIR Phase I: Development and Manufacture of High-Density Plate Washer

SBIR第一期：高密度洗板机的研发与制造

• 批准号: 0319656
• 负责人: Richard Kris
• 金额: $ 10万
• 依托单位: Nuvogen Research
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0319656&HistoricalAwards=false
• 关键词: SBIR; Phase; Development; Manufacture; Density

This Small Business Innovation Research (SBIR) Phase I project proposes to develop a high-density plate washer for very high-density microplates (1536 or more wells per plate). Currently, there are automated plate washers for 96 or 384 well plates that are heavily used for ELISA assays or most other biochemical or cell-based assays. However, there are none for plates with ultra-high density. This is because currently available washer technology cannot be made reliable enough so that dispense and aspirate nozzles consistently reach within each of the many, very small wells, and so that the many thin nozzles needed do not clog. This project will incorporate a wholly innovative design to get around these problems. The proposed technology will allow scientists to wash the 1536 well plates. The implications are that fluoroscent chemical compounds can now be used for screening because they are removed before the measurement of the samples. This will mean cost savings and efficiency in the screening process for both academic and commercial scientists.The commercial application of this project will be a new product that can be used by the research community involved in screening programs for drug discovery.

该小型企业创新研究（SBIR）第一阶段项目建议开发一种用于极高密度微孔板（每个板1536个或更多威尔斯孔）的高密度洗板机。目前，存在用于大量用于ELISA测定或大多数其他生物化学或基于细胞的测定的96或384孔板的自动洗板器。然而，对于超高密度的板没有。这是因为目前可用的清洗器技术不能足够可靠地使得分配和抽吸喷嘴一致地到达许多非常小的威尔斯孔中的每一个孔内，并且使得所需的许多薄喷嘴不会堵塞。 这个项目将采用一个完全创新的设计来解决这些问题。这项拟议中的技术将允许科学家清洗1536孔板。这意味着荧光化合物现在可以用于筛选，因为它们在测量样品之前就被去除了。这将意味着学术和商业科学家在筛选过程中节省成本和效率。该项目的商业应用将是一种新产品，可供参与药物发现筛选计划的研究团体使用。