SENSORS: Collaborative Research: Artificial Cilia- Biologically Inspired Nanosensors

传感器：合作研究：人工纤毛——生物启发纳米传感器

• 批准号: 0329975
• 负责人: Bethanie Stadler
• 金额: $ 19.9万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0329975&HistoricalAwards=false
• 关键词: SENSORS; Collaborative; Research; Artificial; Cilia

Tiny hair-like sensors, or cilia, play a very important role in detection for many biological species, including humans. This research effort takes inspiration from the transduction processes of the inner ear's cochlea and cilia to design acoustic sensors. Specifically, this project proposes to use nanowires of magnetostrictive materials as hair-like sensors of ultrasonic and acoustic signals. The proposed Artificial Cilia Transducers (ACTs) have many advantages over current sensors, as these "magnetic hairs" can be easily fabricated in arrays for enhanced sensitivity and/or spatial resolution as compared to current ultrasonic pressure detectors, and the diameters, lengths and stiffnesses of the hairs can be tailored to a wide range of frequencies. Our unique choice of magnetostrictive materials will enable simultaneous detection of the distinct resonances of multiple cilia using giant magnetoresistive (GMR) sensors. Along with sensor development, several fundamental concepts of science will be investigated as valuable byproducts of this work, including processes for tailoring crystalline texture and grain size at the nanoscale for achieving materials that are more ductile and have larger transduction than their macroscaled counterparts and an understanding of Young's modulus at the nanoscale will be developed through acoustic resonance measurements.Unique contributions to science will be realized as the development of ACTs lead to the ability to discriminate pressure waves with spatial resolutions on the order of the inter-cilia spacing, ~ 40 nm. Other future sensing capabilities (beyond ultrasonic and acoustic signals) could include fluid flow, pressure variations, chemical contamination, and/or magnetic fields. These parameters can be sensed by measuring sonic resonance (as in hydrophone arrays), acoustic resonance chambers (as in the ear's cochlea), hair motion, changes in resonant frequencies due to adsorbed chemicals and hair motion, respectively. Also, future signal processing should enable the detection of frequency, phase, and directionality using nanoarrays. Additionally, the PIs all have strong track records for involving undergraduate students in laboratory research experiences and will continue to do so with this project, including a new collaboration with Morgan State University (an HBCU) that will provide summer internships for Morgan State undergraduate civil Engineering students. The interdisciplinary, inter-institutional nature of this project will be expose undergraduate and graduate students to many unique opportunities.

对于包括人类在内的许多生物物种的检测，微型头发的传感器或纤毛在检测中起着非常重要的作用。 这项研究工作从内耳的耳蜗和纤毛的转导过程中汲取灵感来设计声传感器。 具体而言，该项目提议将磁刻录材料的纳米线用作超声和声学信号的头发传感器。 所提出的人造纤毛传感器（ACT）比当前传感器具有许多优势，因为与当前的超声压力探测器以及直径的直径，头发的直径和刚度相比，这些“磁性头发”可以在阵列中很容易制造，以增强灵敏度和/或空间分辨率，可以将其固定在宽阔的范围内。 我们独特的磁刻录材料选择将同时使用巨型磁盘（GMR）传感器同时检测多个纤毛的独特共振。 随着传感器的开发，将研究这项工作的有价值的副产品，包括纳米级的晶体质地和谷物尺寸的过程，以实现更具延性和更大的转导材料的过程，而不是对大型型号的纳米级促进型，以实现更大的托管材料，并了解纳米级的大型摄入量，并了解其大型型号。行为的发展会导致在基础间距的顺序上以空间分辨率区分压力波的能力，〜40 nm。 其他未来的感应功能（超声波和声信号之外）可能包括流体流动，压力变化，化学污染和/或磁场。 可以通过测量声音共振（如在水文阵列中），声学共振室（如耳朵的耳蜗中），发胶，分别由于吸附的化学物质和头发运动引起的谐振频率的变化来感知这些参数。 同样，将来的信号处理应能够使用纳米阵列检测频率，相位和方向性。此外，PI都有很强的记录记录，可以让本科生参与实验室研究经验，并将继续与该项目一起这样做，包括与摩根州立大学（HBCU）的新合作，将为Morgan State提供暑期实习。 该项目的跨学科，机构间的性质将使本科生和研究生接触到许多独特的机会。