A high-speed network connection for genomics research

该项目建议建立一条暗光纤高性能连接，从基因组研究所（TIGR）连接到马里兰州大学公园的大西洋中部十字路口GigaPoP (MAX)，然后连接到阿比林网络。该光纤将通过FiberGate公司租赁，并将提供高性能和冗余。此外，Abilene/Internet2连接将与位于TIGR一公里半径内的三个附属组织共享。这些机构包括联合技术中心、基因组学发展中心和生物能源替代研究所。该提议的积极方面包括tigr是其测序的微生物有机体科学数据的主要贡献者。TIGR在微生物基因组测序方面的工作帮助了国土防御计划，并支持了对生物恐怖活动的调查。TIGR已经对炭疽杆菌进行了测序，并对菌株之间的遗传差异进行了编目。这种连接将进一步使这项工作成为可能。高性能连接将增加科学数据的交换，并使潜在的新生物信息学应用成为可能。TIGR已经建立了许多研究应用程序，被世界各地的科学家用于进行基因组学研究。该连接将支持几个主要的基于基因组学分析的倡议，涉及美国各地的合作者：建立炭疽病原体炭疽芽孢杆菌遗传变异的综合公共数据库；2. 2 .美国国家科学基金会生命之树项目，以及多机构对代表进化树中许多不同分支的物种基因组进行测序和研究的努力；TIGR与其他五所大学和实验室之间的大规模合作，在基因组学规模上将基因与功能联系起来，以促进对心脏、肺、血液和睡眠功能和疾病的生理和病理生理机制的研究；和4。通过基于网络的数据库和提交给其他公共档案，与科学界共享所有基因组学数据的持续和不断增长的努力。

This project proposes to establish a dark fiber high-performance connection from the Institute for Genomic Research (TIGR) to the MidAtlantic Crossroads GigaPoP (MAX) in College Park, MD and then to the Abilene network. The fiber will be leased through FiberGate, Inc. and will provide both high performance and redundancy. Additionally, the Abilene/Internet2 connection will be shared with three affiliate organizations located within a one-kilometer radius of TIGR. These include the Joint Technology Center, The Center for the Advancement of Genomics and the Institute for Biological Energy Alternatives. Positive aspects of this proposal includeTIGR is a major contributor of scientific data on the microbial organisms that it sequences. TIGR's work in sequencing microbial genomes has aided homeland defense initiatives and supported investigations into bio-terrorist activities. TIGR has sequenced the anthrax bacterium and has been cataloging genetic differences between strains. This connection will further enable this work.A high-performance connection will enable an increased exchange of scientific data and enable potential new bioinformatics applications. TIGR has built numerous research applications that are used by scientist around the world to conduct genomics research. The connection will support several major initiatives for genomics-based analysis involving collaborators across the United States:1. an effort to build a comprehensive public database of genetic variation in the bacterium Bacillus anthracis, the causative agent of anthrax; 2. the NSF Tree of Life project, and multi-institutional effort to sequence and study the genomes of species representing many divergent branches of the evolutionary tree;3. a large-scale collaboration between TIGR and five other universities and laboratories to link genes to function on a genomics scale in order to facilitate investigations in physiological and pathophysiological mechanisms underlying heart, lung, blood, and sleep function and disease; and 4. ongoing and growing effort to share all genomics data with the scientific community, through web-based databases and through submissions to other public archives.