300 MHz NMR console upgrade

核磁共振波谱是一种灵活而强大的研究工具，它使我们能够描述我们所研究或制造的分子的结构。它提供了分子中原子的身份，原子之间如何相互连接，分子中原子的空间关系，分子之间的相互作用以及混合物中不同分子的相对数量的信息。我们的研究使用核磁共振波谱涵盖了广泛的科学问题：从导电聚合物到药物。这项研究产生了新的有用的知识，并为年轻的加拿大科学家提供了培训，他们中的大多数人继续在工业或学术界从事富有成效的职业。如果没有这台核磁共振光谱仪，我们在研究和教育方面的目标是不可能实现的。现代核磁共振波谱仪由一个连接在电子设备上的超导磁体组成，它可以影响或测量磁场的局部小变化。电子元件由独立微处理器组成的小型网络控制，与一台协调和控制核磁共振分析的中央计算机相连，并允许用户操作机器和处理结果数据。我们正在向NSERC申请资金，以帮助更换我们已有13年历史的300 MHz核磁共振光谱仪的电子元件和计算机处理器，该光谱仪在自动化模式下用于快速和常规的质子和碳核磁共振分析合成试剂，中间体和靶标，在维多利亚大学的十个研究小组的研究中。当前的控制台已经过时（23年前的技术），并且越来越多地受到停机和数据传输和存档困难的影响。这一工具发生不可挽回的故障的可能性很高，而且正在迅速增加- -这种事件将严重限制所有10个共同申请人的研究。我们的要求包括几乎所有的光谱仪，除了超导磁体，它继续表现得非常好。这种替换将使我们的核磁共振光谱能力达到现代标准。

Nuclear Magnetic Resonance (NMR) spectroscopy is a flexible and powerful research tool that allows us to describe the structures of the molecules we study or make.  It provides information on the identity of atoms in molecules, how the atoms are connected to one another, the spatial relationships of atoms within molecules, interactions between molecules, and the relative quantities of different molecules in mixtures.  Our research using NMR spectroscopy spans a huge range of scientific problems:  from conducting polymers to pharmaceuticals. This research generates new and useful knowledge and provides training for young Canadian scientists, most of whom go on to productive careers in industry or academia. Achieving our goals in research and education would be impossible without access to this NMR spectrometer.A modern NMR spectrometer consists of a superconducting magnet attached to electronic equipment that allows small, local changes in the magnetic field to be effected or measured.  The electronic components are controlled by a small network of independent microprocessors, linked to a central computer that coordinates and controls the NMR analysis and allows the user to operate the machine and process the resulting data.  We are requesting funds from NSERC to help replace the electronic components and computer processors of our thirteen year-old 300 MHz NMR spectrometer, which is used in automated mode for rapid and routine proton and carbon NMR analysis of synthetic reagents, intermediates and targets in the research of ten research groups at the University of Victoria.  The current console is obsolete (23 year-old technology), and is increasingly subject to downtime and difficulties in data transfer and archiving.  The likelihood of irreparable breakdown of this instrument is high and increasing rapidly - such an event would severely limit the research of all ten co-applicants. Our request comprises almost all of the spectrometer except the superconducting magnet, which continues to perform exceptionally well.  This replacement will bring our NMR spectroscopic capabilities up to modern standards.