FIBR Planning: Genome Dynamics and Evolutionary Processes in a Dioecious System

FIBR 规划：雌雄异株系统中的基因组动力学和进化过程

• 批准号: 0403291
• 负责人: Douglas Taylor
• 金额: $ 4.97万
• 依托单位: University of Virginia Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-03-15 至 2005-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0403291&HistoricalAwards=false
• 关键词: FIBR; Planning; Genome; Dynamics; Evolutionary

Intellectual Merit - Genes on autosomes, on sex-chromosomes, in mitochondria and chloroplasts, and those associated with transposable elements are inherited through different pathways and with different rules. Yet the occurrence of these elements within single individuals, whose phenotype they influence, creates complex evolutionary processes that influence phenomena such as chromosome evolution and genome restructuring. This planning grant has the goal of developing the angiosperm genus Silene and its associated pathogen Microbotryum as model systems for understanding the evolution and genetics of sexual reproductive systems. The Silene - Microbotryum community has successfully developed these species into model systems for the study of sex-determination and host-pathogen systems. The objective of this FIBR planning project is to organize this community around the development of a common set of genomic resources, to integrate the current workers in the field, and to reduce the duplication of effort in developing common resources. A research symposium will be held to achieve this goal and will include not only the scientists working on this system, but also a set of experts in genomics, molecular biology, and theoretical biology who share conceptual interests but work with other organisms. Subsequently, a workshop of the FIBR PIs will be held to develop the proposal itself. This project is centered on the strengths of this system with regard to answering questions that are not readily approachable in other model systems. These strengths include a broad range of systems within closely related taxa, intense knowledge of pathogen dynamics and its interaction with the reproductive system, and a profound understanding of the ecological and phylogeographic context of the evolutionary processes under consideration.Broader Impact - This planning activity will draw together a diverse range of researchers representing a breadth of institutional types and a geographically disperse set. The research symposium emphasizes direct student and post-doctoral participation and builds on the ongoing outreach efforts of the principal investigators. The symposium and planning meetings will provide opportunities to develop further plans for enhancing educational and outreach opportunities as part of the anticipated pre-proposal. More generally, planning for the FIBR pre-proposal will include mechanisms to promote the integration of population dynamic and molecular approaches and help the career development of young scientists by crossing disciplines and emphasizing a broad and comparative approach.

智力优势--常染色体、性染色体、线粒体和叶绿体上的基因，以及那些与转座元件相关的基因，通过不同的途径和不同的规则遗传。然而，这些元素在单个个体中的出现，影响了他们的表型，创造了复杂的进化过程，影响了染色体进化和基因组重组等现象。这项计划赠款的目标是发展被子植物属Silene及其相关病原体Microbotryum，作为了解有性生殖系统的进化和遗传学的模式系统。Silene-Microbotryum群落已经成功地将这些物种发展成性别决定和寄主-病原体系统研究的模式系统。FIBR规划项目的目标是围绕开发一套共同的基因组资源来组织这个社区，整合该领域现有的工作人员，并减少开发共同资源的重复工作。为了实现这一目标，将举行一次研究研讨会，不仅包括致力于这一系统的科学家，还将包括一组基因组学、分子生物学和理论生物学的专家，他们在概念上有共同的兴趣，但与其他生物合作。随后，将举办一次纤维指标研讨会，以制定该提案本身。这个项目的中心是这个系统在回答其他模型系统中不容易接近的问题方面的优势。这些优势包括密切相关的分类群内的广泛系统，对病原体动力学及其与生殖系统的相互作用的深入知识，以及对正在考虑的进化过程的生态和系统地理背景的深刻理解。广泛的影响-这一规划活动将吸引代表广泛的机构类型和地理分散的不同范围的研究人员。研究专题讨论会强调学生和博士后的直接参与，并建立在主要研究人员正在进行的外联工作的基础上。专题讨论会和规划会议将提供机会，作为预期的预提议案的一部分，制定进一步计划，以加强教育和外联机会。更广泛地说，FIBR预建议的规划将包括促进人口动态和分子方法相结合的机制，并通过跨学科和强调广泛和比较的方法来帮助青年科学家的职业发展。