Genetic analysis of metapopulation processes in the Silene-Microbotryum host-pathogen system

Silene-Microbotryum 宿主-病原体系统中复合种群过程的遗传分析

• 批准号: 0919335
• 负责人: Douglas Taylor
• 金额: $ 44.17万
• 依托单位: University of Virginia Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0919335&HistoricalAwards=false
• 关键词: Genetic; analysis; metapopulation; processes; Silene

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).Most organisms exist in populations that are distributed in irregular and often ephemeral patches. This research explores two fundamental consequences of this fact: the forces that create and destroy patterns of genetic variation across a landscape and how these spatial genetic patterns affect responses to disease epidemics and climate change. The research applies high throughput genomic tools to understanding the demographics and genetic dynamics in more than 800 spatially distributed populations. Objectives are to understand how the distribution of organisms in nature affects the establishment, persistence and proliferation of isolated populations, with a particular focus on disease epidemics and host resistance. Understanding the genetics and ecology of interconnected networks of populations is of applied importance for conservation biology, management of genetically modified crops, invasion biology, and understanding the potential of species to respond to global change. The emphasis on disease dynamics and resistance also contributes to understanding the dynamics of human pathogens. The research involves training 10-15 undergraduate and graduate students in the interdisciplinary fields of ecology, genomics, and informatics, with training opportunities designed to enhance participation from members of under-represented groups.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。大多数生物存在于不规则且往往短暂的斑块中分布的种群中。这项研究探讨了这一事实的两个基本后果：创造和破坏景观遗传变异模式的力量，以及这些空间遗传模式如何影响对疾病流行和气候变化的反应。该研究应用高通量基因组工具来了解800多个空间分布人群的人口统计学和遗传动力学。目标是了解自然界中生物的分布如何影响孤立种群的建立，持续和增殖，特别关注疾病流行和宿主抗性。了解种群互联网络的遗传学和生态学对于保护生物学、转基因作物管理、入侵生物学以及了解物种对全球变化的响应潜力具有重要的应用价值。 对疾病动态和抗性的强调也有助于理解人类病原体的动态。该研究涉及在生态学，基因组学和信息学的跨学科领域培训10-15名本科生和研究生，培训机会旨在提高代表性不足的群体成员的参与。