NIRT: Biocatalytic Membrane Nanosystems (BMNs)

NIRT：生物催化膜纳米系统 (BMN)

• 批准号: 0403897
• 负责人: Vadim Guliants
• 金额: --
• 依托单位: University of Cincinnati Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-15 至 2010-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0403897&HistoricalAwards=false
• 关键词: NIRT; Biocatalytic; Membrane; Nanosystems; BMNs

This proposal was received in response to Nanoscale Science and Engineering initiative, NSF 03-043, category NIRT. Recent advances in molecular engineering of ordered nanoporous materials with tunable surface chemistries and their integration into macroscopic architectures offer new, unprecedented opportunities to design highly efficient biomimetic systems for biocatalytic production of pharmaceuticals and other fine chemicals. This NIRT research will design ordered nanoporous silica layers containing encapsulated enzymes as part of Biocatalytic Membrane Nanosystems (BMNs). The fundamental scientific issues underlying the design of highly efficient BMNs will be addressed for two well-characterized and important enzymatic reactions: (1) cofactor-dependent selective oxidation of non-activated carbons by cytochrome P450 BM-3 oxygenase and (2) kinetic resolution of achiral molecules by Pseudomonas cepacia lipase. The integration of various components into fully functioning prototype BMNs will be conducted in parallel with the fundamental studies employing nanoporous silica. This research will lead to improved understanding of nanoscale structure and catalytic function of biomimetic systems and to the design of improved biocatalysts from basic scientific principles.The broader education impacts of this NIRT research are aimed at training of undergraduate and graduate students in the area of molecularly engineered materials for biocatalytic applications. This will be accomplished in part by the outreach efforts directed towards improving higher education opportunities for minority and women engineers by alerting them to the graduate research opportunities at the University of Cincinnati (UC). These efforts will be complemented by a new research effort on societal impacts of nanotechnology that will bring together the UC Institute for Policy Research, leading UC researchers and graduate students in social and physical sciences to develop a plan for integrating the social and technological aspects of nanotechnology.

该提案是响应纳米科学与工程倡议，NSF 03-043，类别NIRT。有序纳米多孔材料的分子工程与可调的表面化学及其整合到宏观架构的最新进展提供了新的，前所未有的机会，设计高效的仿生系统的生物催化生产的药物和其他精细化学品。这项NIRT研究将设计包含包封酶的有序纳米多孔二氧化硅层，作为生物催化膜纳米系统（BMN）的一部分。设计高效BMN的基础科学问题将针对两个充分表征和重要的酶促反应来解决：（1）细胞色素P450 BM-3加氧酶对非活性碳的辅因子依赖性选择性氧化和（2）洋葱假单胞菌脂肪酶对非手性分子的动力学拆分。将各种组件集成到功能齐全的原型BMN中将与采用纳米多孔二氧化硅的基础研究并行进行。这项研究将导致纳米结构和仿生系统的催化功能的理解和改进的生物催化剂的设计，从基本的科学原理，这NIRT研究的更广泛的教育影响，旨在培养本科生和研究生在该地区的分子工程材料的生物催化应用。这将部分通过旨在改善少数族裔和女工程师高等教育机会的外联工作来实现，提醒她们注意辛辛那提大学（UC）的研究生研究机会。这些努力将通过对纳米技术的社会影响的新的研究工作来补充，该研究工作将汇集UC政策研究所，领先的UC研究人员和社会和物理科学研究生，以制定一项整合纳米技术的社会和技术方面的计划。