NER: Nano-Scale Probe Array for Extraction of Genetic Material from Viruses

集成生物芯片是一种很有前途的设备，可以快速准确地检测细胞、细菌、孢子和病毒等生物实体。这些集成的生物芯片需要集中、捕获、裂解和执行基因识别，所有这些都在同一个设备上。图1显示了我们小组正在开发的整体集成生物芯片设备。这些细胞和微生物的准确鉴定需要裂解细胞，提取DNA和蛋白质进行分子鉴定。利用低功耗和集成到微芯片格式的电子手段提取DNA对于实现完全集成的生物分析设备非常有用。该项目的目的是设计和开发一种从病毒中提取遗传物质的方法，该方法在手持设备中，低功耗，使用简单，紧凑。我们将以牛痘病毒西部储备株为模型病毒作为主要目标。作为一个扩展目标，我们将进行人类冠状病毒的实验

Integrated biochips are promising devices for the rapid and accurate detection of biological entities such as cells, bacteria, spores, and viruses. These integrated biochips need to concentrate, trap, lyse, and perform genetic identification, all on the same device. Figure 1 shows an overall integrated biochip device that is being developed in our group. The accurate identification of these cells and microorganisms require the lysing of the cells to extract the DNA and proteins for molecular identification. DNA extraction using electrical means that are low power and integrated on to a microchip format can be very useful for realizing fully integrated bioanalytical devices. The objective of this project is to design and develop a method of extracting the genetic material from viruses within a handheld device which are low power, simple to use and compact. We will work with the Western Reserve Strain of Vaccinia Virus as the model virus as the main goal. As a stretch goal, we will perform the experiments with the Human Coronavirus