NER: Nano-Scale Probe Array for Extraction of Genetic Material from Viruses

集成生物芯片是一种快速、准确地检测细胞、细菌、孢子和病毒等生物实体的有前途的设备。这些集成的生物芯片需要在同一设备上进行浓缩、捕获、裂解和进行遗传鉴定。图1显示了我们团队正在开发的整体集成生物芯片设备。为了准确鉴定这些细胞和微生物，需要裂解细胞以提取DNA和蛋白质进行分子鉴定。使用低功耗并集成到微芯片格式的电子手段提取DNA对于实现完全集成的生物分析设备非常有用。本项目的目标是设计和开发一种从手持设备中的病毒中提取遗传物质的方法，该方法具有功耗低、使用简单和紧凑的特点。我们将以西部储备株痘苗病毒作为模型病毒，作为主要目标。作为延伸目标，我们将对人类冠状病毒进行实验

Integrated biochips are promising devices for the rapid and accurate detection of biological entities such as cells, bacteria, spores, and viruses. These integrated biochips need to concentrate, trap, lyse, and perform genetic identification, all on the same device. Figure 1 shows an overall integrated biochip device that is being developed in our group. The accurate identification of these cells and microorganisms require the lysing of the cells to extract the DNA and proteins for molecular identification. DNA extraction using electrical means that are low power and integrated on to a microchip format can be very useful for realizing fully integrated bioanalytical devices. The objective of this project is to design and develop a method of extracting the genetic material from viruses within a handheld device which are low power, simple to use and compact. We will work with the Western Reserve Strain of Vaccinia Virus as the model virus as the main goal. As a stretch goal, we will perform the experiments with the Human Coronavirus