Career: Silicon-Based Nano Structures and Bio-Sensors for the Nano-BioTechnology Era

职业：纳米生物技术时代的硅基纳米结构和生物传感器

• 批准号: 9984199
• 负责人: Rashid Bashir
• 金额: $ 21万
• 依托单位: Purdue Research Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9984199&HistoricalAwards=false
• 关键词: Career; Silicon; Based; Nano; Structures

As the construction of artificial computational systems continues to become insurmountably difficult, more and more engineers and scientists are turningtowards nature for answers. The time is ripe to begin to better understand biological systems that are self-assembled, sense and relay information, and perform complex computational tasks. Further advances in this area require interdisciplinary researchintegrating nano-electronic engineering and biotechnology to develop functional devices and systems (i.e. nano-biosystems). This proposal details plans for developing semiconductor-based approaches to realize novel nano-biostructures for sensingapplications at the molecular level. These sensing devices will be needed as future hybrid bio-systems start to become closer to reality. Silicon Micro-Electro-Mechanical-Systems (MEMS) will be used in the developmentof the emerging nano-biotechnology area since MEMS techniques can provide ways tointerface the electronic world to the organic or biological world. The proposed research and education components will be carried out within the context of two application domains: (i) Fabrication of silicon-based functionalized scanning probe microscopycantilevers and sensors for single molecule electronic and force detection, and (ii) Silicon-based single molecule counter/sensor devices for applications such as single molecule sensing and DNA/RNA sequencing. The broad research and educational impact of the work willbe a variety of ideas and projects that will contribute to applications such as nano-scalecomputational systems, functional imaging, DNA and protein sequencing, and development of bio-electronic interface devices, all at the molecular level. Furthermore, the grand challenge of education of future researchers and academicians in the area ofnano-biotechnology, which is being faced by the microelectronics and biomedical engineeringdepartments, will also be discussed. The proposal details specific courses at the undergraduate and graduate levels and discusses related activities that will help train students and integrate research and education in the proposed directions of interest.

随着人工计算系统的构建变得越来越困难，越来越多的工程师和科学家转向自然寻求答案。开始更好地理解自我组装、感知和传递信息以及执行复杂计算任务的生物系统的时机已经成熟。这一领域的进一步发展需要跨学科的研究，将纳米电子工程和生物技术结合起来，开发功能器件和系统（即纳米生物系统）。该提案详细说明了开发基于生物传感器的方法以实现分子水平传感应用的新型纳米生物结构的计划。随着未来的混合生物系统开始变得更接近现实，这些传感设备将是必需的。硅微机电系统（MEMS）将用于新兴的纳米生物技术领域的发展，因为MEMS技术可以提供电子世界与有机或生物世界的接口。拟议的研究和教育部分将在两个应用领域内进行：（i）制造硅基功能化扫描探针显微镜，（ii）制造用于单分子电子和力检测的硅基单分子计数器/传感器，（iii）制造用于单分子传感和DNA/RNA测序等应用的硅基单分子计数器/传感器。这项工作的广泛研究和教育影响将是各种各样的想法和项目，这些想法和项目将有助于诸如纳米级计算系统、功能成像、DNA和蛋白质测序以及生物电子接口设备的开发等应用，所有这些都在分子水平上。此外，还将讨论微电子和生物医学工程部门所面临的纳米生物技术领域未来研究人员和学者教育的巨大挑战。该提案详细说明了本科生和研究生一级的具体课程，并讨论了有助于培训学生和将研究与教育结合到拟议的兴趣方向的相关活动。