Nonlinear dynamics of microcantilevers interacting with nanostructures - applications to biomolecular sensing and nanotribology

微悬臂梁与纳米结构相互作用的非线性动力学 - 在生物分子传感和纳米摩擦学中的应用

• 批准号: 0409660
• 负责人: Arvind Raman
• 金额: --
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0409660&HistoricalAwards=false
• 关键词: Nonlinear; dynamics; microcantilevers; interacting; nanostructures

0409660 - Nonlinear dynamics of microcantilevers interacting with nanostructures - applications to biomolecular sensing and nanotribologyThis project explores computationally, and experimentally novel dynamical phenomena underlying the use of scanning probe microcantilevers as mechanical property sensors at the nanoscale. The proposed research targets two applications of key importance in nanostructural property characterization: (a) the measurement and characterization of friction at the nanoscale, and (b) the measurement of mechanical properties of biological macromolecules. In both cases, investigations will be performed to predict the oscillations of microcantilevers in these nanoscale measurement applications. Overall the project will (1) help develop a fundamantal understanding of the physics of atomic scale friciton betweena sharp asperity and nanostructures of interest, especially in sliding speeds of relevance to nanotribology, MEMS and biomolecular systems, (2) help develop design guidelines to tune intentionally the vibration spectrum of these microcantilevers to enhance their performance as nanomechanical property sensors of important biomolecules such as structural proteins and DNA. Finally, the research objectives are complemented by a solid plan for broader impact including specific plans for broader dissemination of research results, increasing participation of minorites and underrepresented groups in research, involving undergraduates in research, and fostering cross disciplinary collaborations with structural biology and condensed matter physics communities on campus.

0409660 -微悬臂梁与纳米结构相互作用的非线性动力学-在生物分子传感和纳米摩擦学中的应用这个项目在计算上和实验上探索了扫描探针微悬臂梁作为纳米级机械性能传感器背后的新动态现象。该研究的目标是纳米结构特性表征的两个关键应用：(a)纳米尺度上摩擦的测量和表征，以及(b)生物大分子力学特性的测量。在这两种情况下，将进行研究，以预测这些纳米尺度测量应用中的微悬臂梁的振荡。总体而言，该项目将(1)有助于对尖锐粗糙体和感兴趣的纳米结构之间原子尺度摩擦的物理原理有一个基本的理解，特别是在与纳米摩擦学、MEMS和生物分子系统相关的滑动速度方面；(2)有助于制定设计指南，有意地调整这些微悬臂的振动谱，以提高它们作为重要生物分子（如结构蛋白和DNA）的纳米力学性能传感器的性能。最后，研究目标是通过一个更广泛影响的坚实计划来补充的，包括更广泛传播研究成果的具体计划，增加少数民族和代表性不足的群体在研究中的参与，让本科生参与研究，以及促进与校园结构生物学和凝聚态物理社区的跨学科合作。