GOALI: Nonlinear, Multi-modal, and Stochastic Dynamics of Low-stiffness Microcantilevers in Liquid Environment Atomic Force Microscopy
目标:液体环境原子力显微镜中低刚度微悬臂梁的非线性、多模态和随机动力学
基本信息
- 批准号:0927648
- 负责人:
- 金额:$ 36.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-08-01 至 2013-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).This project seeks to study the nonlinear, multi-modal, and stochastic dynamics of microcantilevers tapping on samples in liquids to significantly improve next generation dynamic Atomic Force Microscopy (dAFM) for biology and medicine. The proposed work will develop new imaging modes and cantilever designs to greatly enhance nanoscale material property contrast, such as molecular elasticity and recognition, in liquids while applying gentle forces on fragile biological samples including cells, membranes, viruses, and proteins. Accurate mathematical models will be developed to simulate the dynamics of low-stiffness AFM microcantilevers in liquids by systematically including hydrodynamic coupling effects, stochastic Langevin forces, nonlinear tip-sample interactions such as chemical bond forces, and multiple cantilever eigenmodes. Investigations will focus on the dependence of momentary excitation, a non-resonant modal interaction, on: local elasticity and molecular recognition, and bifurcations from single to multiple tapping oscillations. New dAFM modes in buffer solutions will be developed based on these mode coupling phenomena to experimentally resolve variations in local elasticity and molecular recognition on biological molecules in buffer solutions. dAFM has become a major scientific technique for nanometer resolution imaging and materials property characterization. The development of new high-resolution, gentle force, material contrast modes for dAFM of biological samples in liquids would broadly benefit biology and medicine, for example, by providing sensitive maps of protein markers on a cancer cell or drug receptor sites on a cell, thus enabling discoveries in early disease detection and drug discovery. The results could also provide insight into the dynamics of a wider class of systems that are strongly affected by nonlinearities, hydrodynamics and Langevin forces, for example, particles in optical traps, nanomechanical cantilever sensors for biochemical detection in liquids, DNA, biopolymers, and cilia and flagella of eukaryotic cells.
该奖项是根据2009年美国复苏和再投资法案(公法111-5)资助的。该项目旨在研究微悬臂梁在液体样品上的非线性,多模态和随机动力学,以显着改善下一代动态原子力显微镜(dAFM)的生物学和医学。拟议的工作将开发新的成像模式和悬臂梁设计,以大大提高纳米材料特性的对比度,如分子弹性和识别,在液体中,同时对脆弱的生物样品,包括细胞,膜,病毒和蛋白质施加温和的力量。精确的数学模型将被开发来模拟低刚度AFM微悬臂梁在液体中的动力学,系统地包括流体动力学耦合效应,随机朗之万力,非线性针尖样品相互作用,如化学键合力,和多个悬臂梁本征模式。调查将集中在瞬时激励,非共振模态相互作用的依赖性上:局部弹性和分子识别,以及从单个到多个抽头振荡的分叉。基于这些模式耦合现象,将开发缓冲溶液中的新dAFM模式,以实验解决缓冲溶液中生物分子的局部弹性和分子识别的变化。dAFM已成为纳米分辨率成像和材料性能表征的主要科学技术。新的高分辨率,温和的力量,材料对比度模式的液体中的生物样品的dAFM的发展将广泛受益于生物学和医学,例如,通过提供癌细胞上的蛋白质标记物或细胞上的药物受体位点的敏感地图,从而使发现早期疾病检测和药物发现。这些结果也可以提供深入了解更广泛的一类系统的动态,这些系统受到非线性,流体动力学和朗之万力的强烈影响,例如,光阱中的粒子,用于液体中生化检测的纳米机械悬臂梁传感器,DNA,生物聚合物,真核细胞的纤毛和鞭毛。
项目成果
期刊论文数量(0)
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专利数量(0)
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Arvind Raman其他文献
Maximising the potential of academic–practitioner collaborations in international development
最大限度地发挥学术与实践者在国际发展中合作的潜力
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:1.4
- 作者:
Priyanka Brunese;Min K. Lee;Ann Bessenbacher;Arvind Raman;Yuehwern Yih - 通讯作者:
Yuehwern Yih
Nonlinear Dynamics of a Flexible Spinning Disc Coupled to a Precompressed Spring
- DOI:
10.1007/s11071-005-5183-8 - 发表时间:
2005-04-01 - 期刊:
- 影响因子:6.000
- 作者:
Anirban Jana;Arvind Raman - 通讯作者:
Arvind Raman
非線形フォトニック結晶とシリコン・有機ハイブリッド光変調デバイス
非线性光子晶体及硅/有机混合光调制器件
- DOI:
- 发表时间:
2013 - 期刊:
- 影响因子:0
- 作者:
Daniel Kiracofe;Kei Kobayashi;Aleksander Labuda;Arvind Raman;Hirofumi Yamada;井上 振一郎 - 通讯作者:
井上 振一郎
Anisotropic Mechanical Properties of Living Cells Revealed by Integrated Spinning Disk Confocal and Atomic Force Microscopy
- DOI:
10.1016/j.bpj.2017.11.2803 - 发表时间:
2018-02-02 - 期刊:
- 影响因子:
- 作者:
Yuri M. Efremov;Mirian Velay-Lizancos;Daniel M. Suter;Pablo D. Zavattieri;Arvind Raman - 通讯作者:
Arvind Raman
Arvind Raman的其他文献
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{{ truncateString('Arvind Raman', 18)}}的其他基金
GOALI: Visualizing and Measuring Nanoscale Properties through Multi-spectral Atomic Force Microscopy for the Design and Discovery of Novel Materials
GOALI:通过多光谱原子力显微镜可视化和测量纳米级特性,用于新型材料的设计和发现
- 批准号:
1726274 - 财政年份:2017
- 资助金额:
$ 36.5万 - 项目类别:
Standard Grant
SNM: Large Scale Manufacturing of Low-Cost Functionalized Carbon Nanomaterials for Energy Storage and Biosensor Applications
SNM:大规模制造用于储能和生物传感器应用的低成本功能化碳纳米材料
- 批准号:
1344654 - 财政年份:2013
- 资助金额:
$ 36.5万 - 项目类别:
Standard Grant
Nonlinear Dynamics and Bifurcations of Human Posture on Tunable Balance Boards
可调谐平衡板上人体姿势的非线性动力学和分叉
- 批准号:
1300632 - 财政年份:2013
- 资助金额:
$ 36.5万 - 项目类别:
Standard Grant
Colombia-U.S. Workshop on Nanotechnology in Energy and Medical Applications
哥伦比亚-美国
- 批准号:
1157747 - 财政年份:2012
- 资助金额:
$ 36.5万 - 项目类别:
Standard Grant
Materials World Network: Probing in-Vitro Structure-Property-Function Relationships of Ciruses at High-Resolution using Advanced Atomic Force Microscopy Methods
材料世界网络:使用先进原子力显微镜方法以高分辨率探测 Ciruses 的体外结构-性质-功能关系
- 批准号:
1008189 - 财政年份:2010
- 资助金额:
$ 36.5万 - 项目类别:
Standard Grant
Nonlinear Dynamics of Microcantilevers Interacting with Nanostructures: New Paradigms for Ultrasensitive Atomic Force Microscopy
微悬臂梁与纳米结构相互作用的非线性动力学:超灵敏原子力显微镜的新范例
- 批准号:
0700289 - 财政年份:2007
- 资助金额:
$ 36.5万 - 项目类别:
Standard Grant
Nonlinear dynamics of microcantilevers interacting with nanostructures - applications to biomolecular sensing and nanotribology
微悬臂梁与纳米结构相互作用的非线性动力学 - 在生物分子传感和纳米摩擦学中的应用
- 批准号:
0409660 - 财政年份:2004
- 资助金额:
$ 36.5万 - 项目类别:
Continuing Grant
CAREER: Nonlinear Mechanics and Aeroelastic Stability of High-Speed Rotating Disks and Translating Webs
职业:高速旋转盘和平移腹板的非线性力学和气动弹性稳定性
- 批准号:
0134455 - 财政年份:2002
- 资助金额:
$ 36.5万 - 项目类别:
Standard Grant
Vibrations and Nonlinear Dynamics of Microcantilevers Interacting with Nanoscale Structures: Applications to Atomic Force Microscopy
与纳米级结构相互作用的微悬臂梁的振动和非线性动力学:在原子力显微镜中的应用
- 批准号:
0116414 - 财政年份:2001
- 资助金额:
$ 36.5万 - 项目类别:
Standard Grant
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