Cleavage and Formation of C-S and C-N Bonds in Heterocyclic Compounds by Homogeneous Transition Metal Complexes

均相过渡金属配合物对杂环化合物中 C-S 和 C-N 键的断裂和形成

• 批准号: 0414325
• 负责人: William Jones
• 金额: $ 40万
• 依托单位: University of Rochester
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0414325&HistoricalAwards=false
• 关键词: Cleavage; Formation; Bonds; Heterocyclic; Compounds

This award in the Inorganic, Bioinorganic and Organometallic Chemistry Program supports research by Professor William D. Jones at the University of Rochester to develop new hydrodesulfurization techniques and synthetic applications for the cleavage and formation of C-S and C-N bonds in thiophenes and heterocyclic nitrogen containing compounds with transition metal fragments. The objectives are to: (1) provide basic information about the requirements for the cleavage of these strong and/or hindered C-X bonds (X = S, N), (2) provide information about the mechanism(s) for C-X bond cleavage, (3) examine structural motifs for the binding of sulfur- and nitrogen-containing organic compounds to metals, (4) understand the chemistry of metal sulfhydryl and sulfido compounds, their interconversion, and their lability, and (5) develop catalytic systems for manipulation of C-S and C-N bonds. New concepts to be explored include the determination of electronic effects on bond cleavage and the use of supported systems for catalysis. Both undergraduate and graduate students will be trained at an advanced level to use the concepts of inorganic, organic, analytical, and physical. The University of Rochester has a joint program with Hampton University to attract students from underrepresented groups from the Hampton M.S. program directly into the Rochester Ph.D. program. The scientific work is aimed at a better understanding of how to desulfurize the most resistant polyalkylated dibenzothiophenes still found in hydrocarbon fuels. This knowledge will help in meeting the new EPA standards for low sulfur emissions from fuels. Another impact of the work is in developing new synthetic routes to nitrogen-containing heterocycles, a fundamental building block in many biologically important compounds.

这个奖项在无机，生物无机和有机化学计划支持研究教授威廉D。Jones在罗切斯特大学开发新的加氢脱硫技术和合成应用，用于噻吩和具有过渡金属片段的杂环含氮化合物中C-S和C-N键的断裂和形成。 其目标是：（1）提供关于断裂这些强和/或受阻C-X键的要求的基本信息，（X = S，N），（2）提供有关C-X键断裂机制的信息，（3）检查含硫和含氮有机化合物与金属结合的结构基序，（4）了解金属巯基和硫基化合物的化学，它们的相互转化，和不稳定性;（5）开发用于操纵C-S和C-N键的催化体系。 新的概念，以探讨包括确定电子效应的键断裂和使用支持系统的催化。本科生和研究生都将接受高级培训，以使用无机，有机，分析和物理的概念。罗切斯特大学与汉普顿大学有一个联合项目，以吸引来自汉普顿M. S.的代表性不足群体的学生。直接进入罗切斯特的博士课程程序. 这项科学工作的目的是更好地了解如何脱硫仍然在碳氢燃料中发现的最具抗性的多烷基化二苯并噻吩。这些知识将有助于满足新的EPA燃料低硫排放标准。 这项工作的另一个影响是开发了含氮杂环的新合成路线，这是许多生物重要化合物的基本组成部分。