Cleavage and Formation of C-S and C-N Bonds in Heterocyclic Compounds by Homogeneous Transition Metal Complexes

均相过渡金属配合物对杂环化合物中 C-S 和 C-N 键的断裂和形成

• 批准号: 0414325
• 负责人: William Jones
• 金额: $ 40万
• 依托单位: University of Rochester
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0414325&HistoricalAwards=false
• 关键词: Cleavage; Formation; Bonds; Heterocyclic; Compounds

This award in the Inorganic, Bioinorganic and Organometallic Chemistry Program supports research by Professor William D. Jones at the University of Rochester to develop new hydrodesulfurization techniques and synthetic applications for the cleavage and formation of C-S and C-N bonds in thiophenes and heterocyclic nitrogen containing compounds with transition metal fragments. The objectives are to: (1) provide basic information about the requirements for the cleavage of these strong and/or hindered C-X bonds (X = S, N), (2) provide information about the mechanism(s) for C-X bond cleavage, (3) examine structural motifs for the binding of sulfur- and nitrogen-containing organic compounds to metals, (4) understand the chemistry of metal sulfhydryl and sulfido compounds, their interconversion, and their lability, and (5) develop catalytic systems for manipulation of C-S and C-N bonds. New concepts to be explored include the determination of electronic effects on bond cleavage and the use of supported systems for catalysis. Both undergraduate and graduate students will be trained at an advanced level to use the concepts of inorganic, organic, analytical, and physical. The University of Rochester has a joint program with Hampton University to attract students from underrepresented groups from the Hampton M.S. program directly into the Rochester Ph.D. program. The scientific work is aimed at a better understanding of how to desulfurize the most resistant polyalkylated dibenzothiophenes still found in hydrocarbon fuels. This knowledge will help in meeting the new EPA standards for low sulfur emissions from fuels. Another impact of the work is in developing new synthetic routes to nitrogen-containing heterocycles, a fundamental building block in many biologically important compounds.

这个无机、生物无机和有机金属化学项目的奖项支持罗切斯特大学的William D. Jones教授的研究，以开发新的加氢脱硫技术和合成应用，用于在噻吩和含过渡金属碎片的杂环氮化合物中裂解和形成C-S和C-N键。目标是：(1)提供有关这些强和/或受阻的C-X键（X = S， N）裂解要求的基本信息，(2)提供有关C-X键裂解机制的信息，(3)研究含硫和含氮有机化合物与金属结合的结构基序，(4)了解金属硫羟基和硫化合物的化学性质，它们的相互转化及其稳定性，以及(5)开发操纵C-S和C-N键的催化体系。要探索的新概念包括电子对键解理的影响的测定和支持系统催化的使用。本科生和研究生都将在使用无机、有机、分析和物理概念的高级水平上接受训练。罗彻斯特大学与汉普顿大学有一个联合项目，吸引来自汉普顿硕士项目中代表性不足群体的学生直接进入罗彻斯特博士项目。这项科学工作的目的是更好地了解如何脱硫仍在碳氢燃料中发现的最耐腐蚀的多烷基二苯并噻吩。这些知识将有助于满足美国环保署关于燃料低硫排放的新标准。这项工作的另一个影响是开发了含氮杂环的新合成途径，杂环是许多重要生物化合物的基本组成部分。