Organometallic Chemistry of Heterocycles
杂环有机金属化学
基本信息
- 批准号:1360985
- 负责人:
- 金额:$ 42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-09-01 至 2018-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In this project funded by the Chemical Catalysis program of the Chemistry Division, Professor William Jones of the University of Rochester is examining new reactions that can be used to make organic compounds of interest in biology and the pharmaceutical industry. To accomplish this, fundamental reactions of transition metal catalysts are being examined that can be used to form heterocycles from readily available, inexpensive starting materials. Professor Jones is also examining new catalysts that can break open heterocycles and allow their structures to be altered.The broader impacts of this work include outreach to high school students to attract interest to careers in STEM related fields, as well as the development of new processes for routes to intermediates of pharmaceutical importance. The combination of a detailed physical-organometallic background combined with an understanding of how to apply modern computational methods to these problems produces extremely well trained scientists for the US chemical industry. One specific goal of this project is to examine fundamental aspects of cyclometallation via the "Concerted Metallation-Deprotonation" pathway that is now popular in organic synthetic methodology to produce heterocycles. These cyclometallation studies are revealing fundamental aspects of how these molecules effect the chemical transformations, and are providing insight into the control of the selectivity that is critical to formation of the desired product. A second goal is to develop uses for the now commonly observed transition metal based carbon-sulfur bond cleavage sulfur-containing molecules. One application involves anchoring a reversible carbon-sulfur activation catalyst to a solid support that allows this material to act as a "sulfur sponge," thereby permitting the cleanup of hydrocarbon fuels prior to combustion.
在这个由化学部化学催化项目资助的项目中,罗切斯特大学的威廉·琼斯教授正在研究可用于制造生物学和制药工业感兴趣的有机化合物的新反应。为了实现这一目标,正在研究过渡金属催化剂的基本反应,这些反应可用于从容易获得、廉价的起始材料形成杂环。 琼斯教授还在研究可以打破杂环并改变其结构的新催化剂。这项工作的更广泛影响包括向高中生推广,以吸引他们对 STEM 相关领域的职业兴趣,以及开发具有药物重要性的中间体路线的新工艺。 详细的物理有机金属背景与对如何应用现代计算方法解决这些问题的理解相结合,为美国化学工业培养了训练有素的科学家。该项目的一个具体目标是通过“协同金属化-去质子化”途径来研究环金属化的基本方面,该途径目前在生产杂环的有机合成方法中很流行。 这些环金属化研究揭示了这些分子如何影响化学转化的基本方面,并提供了对选择性控制的深入了解,这对于所需产物的形成至关重要。 第二个目标是开发现在常见的基于过渡金属的碳硫键断裂含硫分子的用途。 一种应用涉及将可逆碳硫活化催化剂锚定到固体载体上,使该材料充当“硫海绵”,从而允许在燃烧之前净化碳氢化合物燃料。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Synthesis, characterization, and reactivity of Cp*Rh(III) complexes having functional N,O chelate ligands
- DOI:10.1016/j.jorganchem.2017.02.015
- 发表时间:2017-10
- 期刊:
- 影响因子:2.3
- 作者:Lloyd Munjanja;Hong-Zhong Yuan;W. Brennessel;W. Jones
- 通讯作者:Lloyd Munjanja;Hong-Zhong Yuan;W. Brennessel;W. Jones
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William Jones其他文献
Maximising stakeholder learning by looping again through the simulation life-cycle: A case study in public transport
通过再次循环模拟生命周期来最大化利益相关者的学习:公共交通案例研究
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:3.6
- 作者:
William Jones;Kathy Kotiadis;J. O’Hanley - 通讯作者:
J. O’Hanley
Stakeholders To Extend The Lifecycle Of Hybrid Simulation Models
利益相关者延长混合仿真模型的生命周期
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
William Jones;Kathy Kotiadis;Jesse O’Hanley - 通讯作者:
Jesse O’Hanley
Association between psoas major muscle mass and CPET performance and long-term survival following major colorectal surgery: A retrospective cohort study.
腰大肌质量与 CPET 表现以及大结直肠手术后长期生存之间的关联:一项回顾性队列研究。
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
S. Hajibandeh;Iain Gilham;Winnie Tam;Emma Kirby;Adetona O Babs;William Jones;George A. Rose;Damian M. Bailey;C. Morris;Rachel Hargest;Amy Clayton;Richard G. Davies - 通讯作者:
Richard G. Davies
Personal Information Management
个人信息管理
- DOI:
10.1081/e-elis4-120053695 - 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
William Jones;J. Dinneen;Robert G. Capra;A. Diekema;Manuel A. Pérez - 通讯作者:
Manuel A. Pérez
UNDETERMINED CAUSE OF DEATH: A POOLED ANALYSIS OF 9,307 DEATHS ACROSS 9 CARDIOVASCULAR TRIALS
- DOI:
10.1016/s0735-1097(18)30631-4 - 发表时间:
2018-03-10 - 期刊:
- 影响因子:
- 作者:
Alexander C. Fanaroff;Robert Clare;Karen Pieper;Kenneth Mahaffey;Chiara Melloni;Jennifer Green;John Alexander;William Jones;Robert Harrison;Rajendra Mehta;Thomas Povsic;Humberto Moreira;Sana Al-Khatib;Matthew Roe;David Kong;Robin Mathews;Pierluigi Tricoci;Rury Holman;Lars Wallentin;Claes Held - 通讯作者:
Claes Held
William Jones的其他文献
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{{ truncateString('William Jones', 18)}}的其他基金
Electrocatalytic Oxidation of Alcohols, Amines, and Carbon-Carbon Bonds
醇、胺和碳-碳键的电催化氧化
- 批准号:
1762350 - 财政年份:2018
- 资助金额:
$ 42万 - 项目类别:
Standard Grant
MRI: Acquisition of an X-Ray Diffractometer
MRI:获取 X 射线衍射仪
- 批准号:
1725028 - 财政年份:2017
- 资助金额:
$ 42万 - 项目类别:
Standard Grant
(UKCTRF) UK Consortium on Turbulent Reacting Flows
(UKCTRF) 英国湍流反应流联盟
- 批准号:
EP/K026801/1 - 财政年份:2014
- 资助金额:
$ 42万 - 项目类别:
Research Grant
Probing Fundamental Physics with the Spider Antarctic Long Duration Balloon Experiment
通过蜘蛛南极长时间气球实验探索基础物理
- 批准号:
1043515 - 财政年份:2011
- 资助金额:
$ 42万 - 项目类别:
Standard Grant
Cleavage and Formation of C-S and C-N Bonds in Heterocyclic Compounds by Homogeneous Transition Metal Complexes
均相过渡金属配合物对杂环化合物中 C-S 和 C-N 键的断裂和形成
- 批准号:
1012405 - 财政年份:2010
- 资助金额:
$ 42万 - 项目类别:
Standard Grant
RATE-CONTROLLED CONSTRAINED EQUILIBRIUM: A BASIS FOR EFFECTIVE COUPLING OF COMPREHENSIVE CHEMICAL KINETICS AND CFD
速率控制约束平衡:综合化学动力学与 CFD 有效耦合的基础
- 批准号:
EP/G05679X/1 - 财政年份:2010
- 资助金额:
$ 42万 - 项目类别:
Research Grant
Cleavage and Formation of C-S and C-N Bonds in Heterocyclic Compounds by Homogeneous Transition Metal Complexes
均相过渡金属配合物对杂环化合物中 C-S 和 C-N 键的断裂和形成
- 批准号:
0717040 - 财政年份:2007
- 资助金额:
$ 42万 - 项目类别:
Continuing Grant
Structuring Personal Information Collections
构建个人信息收集
- 批准号:
0534386 - 财政年份:2006
- 资助金额:
$ 42万 - 项目类别:
Continuing Grant
Cleavage and Formation of C-S and C-N Bonds in Heterocyclic Compounds by Homogeneous Transition Metal Complexes
均相过渡金属配合物对杂环化合物中 C-S 和 C-N 键的断裂和形成
- 批准号:
0414325 - 财政年份:2004
- 资助金额:
$ 42万 - 项目类别:
Continuing Grant
NSF Workshop on Personal Information Management
NSF 个人信息管理研讨会
- 批准号:
0435134 - 财政年份:2004
- 资助金额:
$ 42万 - 项目类别:
Standard Grant
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