"Beyond a Supramolecular Approach to Structure and Reactivity of Organic Molecules"

哥伦比亚大学化学系的Nicholas Turro教授得到了有机和大分子化学项目的支持，他的研究将(1)研究吸附在一系列单分散沸石晶体外表面的分子结构和动力学的EPR表征；(2)研究了单重态氧与吸附在沸石内表面的氨基甲酸酯反应的立体选择性；(3)研究末端标记为电子激发态、活性自由基或电子自旋极化态的大分子与小分子（作为自由基聚合中传播步骤的模型）和与其他大分子链末端（作为自由基聚合中终止步骤的模型）的相互作用；(4)探索两个光子同时吸收诱导长波光的光化学反应。这些研究活动将通过多种技术方法进行调查，包括时间分辨光谱方法（紫外-可见吸收，荧光，磷光，红外，电子顺磁共振和核磁共振）。有了这个奖项，有机和大分子化学项目继续支持哥伦比亚大学Nicholas J. Turro教授的研究活动，除了其内在的科学兴趣外，鉴于沸石在各种工业过程中作为催化剂的重要性，本提案中的沸石表征项目具有实际意义。聚合物动力学项目也具有明显的工业意义。多光子研究可能会导致一种用荧光探针标记生物大分子的方法，这种荧光探针可以在体内被仅被组织微弱吸收的长波光激活。Turro教授活动的更广泛影响包括通过使用光谱学和光化学这两个主题将研究和教育结合起来，作为在本科课程中开展化学讲座和化学实验室的概念基础。在过去的资助期内，Turro教授通过担任15名研究生，23名博士后，10名本科生和3名高中教师的导师，为科学人力资源池的多样性做出了贡献。这一组包括11名女性和6名少数民族学生。

Professor Nicholas Turro, of the Department of Chemistry at Columbia University, is supported by the Organic and Macromolecular Chemistry Program for his studies that will (1) investigate the EPR characterization of the structure and dynamics of molecules adsorbed on the external surface of a series of monodispersed zeolite crystals; (2) study the stereoselectivity of the reaction of singlet oxygen with enecarbamates adsorbed on the internal surface of zeolites; (3) examine the interactions of macromolecules end-labeled with an electronically excited state, a reactive radical or an electron spin polarized state with small molecules (as a model for the propagation step in free radical polymerization) and with the ends of other macromolecular chains (as a model for the termination step in free radical polymerization); and (4) explore the simultaneous absorption of two photons to induce photochemistry with long wavelength light. Each of these research activities will be investigated through a multi-technique approach including time resolved spectroscopic methods (UV-VIS absorption, fluorescence, phosphorescence, infrared, electron paramagnetic resonance and nuclear magnetic resonance).With this Award, the Organic and Macromolecular Chemistry Program continues its support of the research activities of Professor Nicholas J. Turro of Columbia University where in addition to its intrinsic scientific interest, the zeolite characterization project in this proposal is of practical significance given the importance of zeolites as catalysts in various industrial processes. The polymer kinetics project has obvious industrial significance as well. The multiphoton studies could lead to a method of tagging biological macromolecules with fluorescent probes that can be activated in vivo by long wavelength light that is only weakly absorbed by the tissues. Broader impacts of Professor Turro's activities include the integration of research and education through the use of the twin themes of spectroscopy and photochemistry as a conceptual basis for developing chemistry lectures and chemistry laboratories in undergraduate courses. During the past funding period Professor Turro has contributed to diversity in the human resource pool for science by serving as a mentor for 15 graduate students, 23 postdoctoral associates, 10 undergraduates and 3 high school teachers. This group included 11 women and 6 minority students.