Purchase of a AC-80 NMR Spectrometer

购买AC-80核磁共振波谱仪

• 批准号: 9520633
• 负责人: Nicholas Turro
• 金额: $ 7.6万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-06-01 至 1997-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9520633&HistoricalAwards=false
• 关键词: Purchase; AC; 80; NMR; Spectrometer

This award from the Chemistry Research Instrumentation Program will help the Department of Chemistry at Columbia University acquire an AC-80 NMR spectrometer that will operate as a multiuser steady state (SS) and time resolved (TR) instrument for the detection of chemically induced dynamic nuclear polarization (CIDNP). The Principal Investigators will employ the instrument to investigate, by multinuclear (1H, 13C, 31P) SS-CIDNP and TR-CIDNP, the mechanisms of diverse photochemical systems including (1) the reactions of organic radical ions produced by photosensitized electron transfer; (2) the photochemistry of phosphites and phosphine oxides; (3) the measurement of exit rates of radicals, produced by photolysis of ketone from micelles as a function of micelle size and radical structure; (4) the photosensitized cleavage of thymine dimers in systems that model photoinduced repair of damaged DNA; (5) a search for CIDNP in oriented biological macromolecular solids; and (6) time resolved CIDNP of biradicals produced by photolysis of cyclic ketones. In addition to the research described above, the instrumentation will be used by undergraduates in advanced organic chemistry laboratories, in physical-analytical laboratories, in research project laboratories, in senior research and in summer undergraduate research. The instrument will be coupled into an "electronic smart classroom" containing state-of-the-art multimedia facilities to allow students and faculty to introduce data directly from experiments into lecture, recitation and discussion groups on demand. Finally, the computer interface will be employed to produce modules that will simulate important NMR experiments and will be accessible to students on their own personal computers through ColumbiaNet. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to the chemist for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arra ngements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in areas such as polymers and catalysis, and in biology.

化学研究仪器计划的这一奖项将帮助哥伦比亚大学化学系获得AC-80 NMR光谱仪，该光谱仪将作为多用户稳态（SS）和时间分辨（TR）仪器用于检测化学诱导动态核极化（CIDNP）。 主要研究者将使用该仪器通过多核（~ 1H，~（13）C，~（31）P）SS-CIDNP和TR-CIDNP等光化学体系的机理，包括：（1）光敏电子转移产生的有机自由基离子反应，（2）亚磷酸酯和氧化膦的光化学反应，（3）光化学反应机理。（3）测定胶束中酮光解产生的自由基的排出速率，作为胶束尺寸和自由基结构的函数;（4）在模拟受损DNA的光诱导修复的系统中胸腺嘧啶二聚体的光敏裂解;（5）在定向生物大分子固体中寻找CIDNP;（6）由环酮光解产生的双自由基的时间分辨CIDNP。 除了上述研究外，仪器还将用于高级有机化学实验室，物理分析实验室，研究项目实验室，高级研究和夏季本科生研究。 该仪器将被耦合到一个“电子智能教室”，其中包含最先进的多媒体设施，使学生和教师能够根据需要将实验数据直接引入讲座，背诵和讨论小组。 最后，计算机接口将被用来产生模拟重要的核磁共振实验的模块，并将通过ColumbiaNet在自己的个人计算机上提供给学生。 核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具。 它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。 对于进行前沿研究的化学家来说，使用最先进的核磁共振光谱法至关重要。 这些NMR研究的结果在聚合物和催化以及生物学等领域都很有用。