Well-Defined Protein-Polymer Conjugates Prepared by Controlled Radical Polymerization

通过受控自由基聚合制备结构明确的蛋白质-聚合物缀合物

• 批准号: 0416359
• 负责人: Heather Maynard
• 金额: --
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0416359&HistoricalAwards=false
• 关键词: Well; Defined; Protein; Polymer; Conjugates

This research program focuses on the development of versatile methods for the preparation of well-defined polymer bioconjugates by conjugating activated homogeneous polymers to biomolecules and initiating controlled polymerization from proteins in aqueous solution. New bifunctional initiators for atom transfer radical polymerization will be used to prepare monodisperse polymers that react with specific protein residues, and controlled polymerization initiated by modified proteins in aqueous solution will generate bioconjugates in situ.With the support of the Organic and Macromolecular Chemistry Program, Professor Heather D. Maynard, of the Department of Chemistry and Biochemistry at the University of California, Los Angeles, is developing new methods to prepare couple conventional polymers with polypeptides (proteins). Material properties and applications of such protein-polymer "conjugates" in nanostructured materials, drug delivery, smart materials, and therapeutics are critically dependent on having well-defined polymers and specific points of attachment, yet these are extremely difficult to achieve by conventional means. Professor Maynard's research targets the development of novel new approaches for the synthesis of such structurally and functionally well-defined conjugates.

该研究项目的重点是开发多功能方法，通过将活化的均相聚合物与生物分子结合，并在水溶液中从蛋白质中引发受控聚合，制备定义明确的聚合物生物缀合物。新的双功能原子转移自由基聚合引发剂将用于制备单分散聚合物，与特定的蛋白质残基反应，并在水溶液中由改性蛋白质引发的可控聚合将原位生成生物缀合物。位于洛杉矶的加州大学化学和生物化学系的梅纳德正在开发新的方法来制备与多肽（蛋白质）偶联的常规聚合物。这种蛋白质-聚合物“缀合物”在纳米结构材料、药物递送、智能材料和治疗学中的材料性质和应用关键地取决于具有明确定义的聚合物和特定的连接点，然而这些通过常规手段极难实现。Maynard教授的研究目标是开发新的新方法来合成这种结构和功能明确的缀合物。