CAREER: EFFICIENT CHEMICAL REACTIONS TO PATTERN AND ARRAY PROTEINS AT THE MICRON AND NANOSCALE

职业：在微米和纳米尺度上对蛋白质图案和阵列进行高效化学反应

• 批准号: 0645793
• 负责人: Heather Maynard
• 金额: $ 60万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0645793&HistoricalAwards=false
• 关键词: CAREER; EFFICIENT; CHEMICAL; REACTIONS; PATTERN

The Analytical and Surface Chemistry (ASC) program of the Division of Chemistry will support the CAREER development plan of Heather D. Maynard of the Department of Chemistry and Biochemistry at the University of California, Los Angeles. Prof. Maynard and her students will develop methods to pattern proteins on surfaces at the micron and nanometer scale using advanced lithographic techniques. These techniques will be used to chemically transform self assembled monolayers (SAMs) into micro and nano-patterns of reactive aldehydes. Proteins will be conjugated to these surfaces by first patterning streptavidin and then attaching biotinylated proteins to the surface. The resulting materials will be suitable in a wide variety of applications including diagnostics for human diseases. The project will provide excellent educational training opportunities to students in the biological aspects of nanotechnology and will to address growing workforce needs. Particular emphasis will be placed on recruiting underrepresented minorities into this new field.

化学系的分析和表面化学（ASC）计划将支持石楠D的职业发展计划。位于洛杉矶的加州大学化学和生物化学系的梅纳德说。 Maynard教授和她的学生将开发方法，使用先进的光刻技术在微米和纳米尺度的表面上形成蛋白质图案。 这些技术将被用于化学转化自组装单分子膜（SAMs）成反应性醛的微米和纳米图案。蛋白质将通过首先使链霉亲和素图案化，然后将生物素化的蛋白质附着到表面而缀合到这些表面。 所得材料将适用于各种各样的应用，包括人类疾病的诊断。 该项目将为学生提供纳米技术生物方面的良好教育培训机会，并将满足日益增长的劳动力需求。 将特别强调征聘代表性不足的少数群体进入这一新领域。