CAREER: EFFICIENT CHEMICAL REACTIONS TO PATTERN AND ARRAY PROTEINS AT THE MICRON AND NANOSCALE

化学系的分析与表面化学（ASC）项目将支持加州大学洛杉矶分校化学与生物化学系Heather D. Maynard的职业发展计划。梅纳德教授和她的学生将开发利用先进的光刻技术在微米和纳米尺度的表面上绘制蛋白质图案的方法。这些技术将用于将自组装单层（sam）化学转化为微纳米模式的反应性醛。蛋白质将首先通过链亲和素的图案结合到这些表面，然后将生物素化的蛋白质附着在表面上。由此产生的材料将适用于各种各样的应用，包括对人类疾病的诊断。该项目将为学生提供纳米技术生物学方面的优秀教育培训机会，并将满足日益增长的劳动力需求。将特别强调招募代表性不足的少数民族进入这个新领域。

The Analytical and Surface Chemistry (ASC) program of the Division of Chemistry will support the CAREER development plan of Heather D. Maynard of the Department of Chemistry and Biochemistry at the University of California, Los Angeles. Prof. Maynard and her students will develop methods to pattern proteins on surfaces at the micron and nanometer scale using advanced lithographic techniques. These techniques will be used to chemically transform self assembled monolayers (SAMs) into micro and nano-patterns of reactive aldehydes. Proteins will be conjugated to these surfaces by first patterning streptavidin and then attaching biotinylated proteins to the surface. The resulting materials will be suitable in a wide variety of applications including diagnostics for human diseases. The project will provide excellent educational training opportunities to students in the biological aspects of nanotechnology and will to address growing workforce needs. Particular emphasis will be placed on recruiting underrepresented minorities into this new field.