CAREER: EFFICIENT CHEMICAL REACTIONS TO PATTERN AND ARRAY PROTEINS AT THE MICRON AND NANOSCALE

化学系的分析和表面化学(ASC)计划将支持加州大学洛杉矶分校化学和生物化学系的Heather D.Maynard的职业发展计划。梅纳德教授和她的学生将开发使用先进的光刻技术在微米和纳米级的表面上绘制蛋白质图案的方法。这些技术将被用来将自组装单分子膜(SAM)化学转化为反应性醛的微米和纳米图案。蛋白质将通过首先构图链霉亲和素，然后将生物素化的蛋白质附着在表面上而连接到这些表面。由此产生的材料将适用于广泛的应用，包括对人类疾病的诊断。该项目将在纳米技术的生物学方面为学生提供极好的教育培训机会，并将满足日益增长的劳动力需求。将特别重视招募代表人数不足的少数群体进入这一新领域。

The Analytical and Surface Chemistry (ASC) program of the Division of Chemistry will support the CAREER development plan of Heather D. Maynard of the Department of Chemistry and Biochemistry at the University of California, Los Angeles. Prof. Maynard and her students will develop methods to pattern proteins on surfaces at the micron and nanometer scale using advanced lithographic techniques. These techniques will be used to chemically transform self assembled monolayers (SAMs) into micro and nano-patterns of reactive aldehydes. Proteins will be conjugated to these surfaces by first patterning streptavidin and then attaching biotinylated proteins to the surface. The resulting materials will be suitable in a wide variety of applications including diagnostics for human diseases. The project will provide excellent educational training opportunities to students in the biological aspects of nanotechnology and will to address growing workforce needs. Particular emphasis will be placed on recruiting underrepresented minorities into this new field.