Vascular Pattern Formation in Leaves of Arabidopsis

拟南芥叶中维管束模式的形成

• 批准号: 0416731
• 负责人: Timothy Nelson
• 金额: $ 47万
• 依托单位: Yale University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-15 至 2008-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0416731&HistoricalAwards=false
• 关键词: Vascular; Pattern; Formation; Leaves; Arabidopsis

Proposal 0416731Vascular Pattern Formation in Leaves of Arabidopsis This project seeks to understand the progressive building of vein networks during the development of plant leaves. A hierarchy of primary, secondary and higher order veins appears during the formation of a leaf. This provides landmarks that position other types of cells that carry out photosynthesis, gas exchange, sugar transport and other functions with an essential relationship to the vein system. The vein pattern of a particular species is not fixed, and it can be optimized to the requirements of the environment to provide greater photosynthetic or water efficiency when needed. This project has used genetics and molecular biology to identify several dozen genes and gene products with potential roles in the vein patterning process. The current project will follow through on understanding the roles of the products of these key genes, some of which are members of biochemical pathways for signaling within or between cells (e.g., sterols). What are the targets of these signals, and what triggers them at the right time and place to form continuous files of vein cells? The project will identify the immediate triggers and targets for these signals, using the currently identified gene products to find the unknown ones, and to bootstrap along to additional partners. The scientific impact of this will be to increase the understanding of venation formation, providing potential tools for modifying the adaptation of plants to different environments or the efficiency of plant growth. The broader impact of the project is that it serves as a training vehicle for graduate students and postdoctoral scientists, and as a source of materials for the PI's teaching to undergraduate and graduate students. The PI is active in teaching biology to non-science undergraduates, many of whom have an interest in working on science policy and science & society issues.

拟南芥叶片维管模式的形成本项目旨在了解植物叶片发育过程中静脉网络的逐步建立。在叶片的形成过程中出现初级、次级和高级脉的层次。这为其他类型的细胞提供了定位的标志，这些细胞进行光合作用、气体交换、糖运输和其他与静脉系统有重要关系的功能。特定物种的静脉模式不是固定的，它可以根据环境的要求进行优化，在需要时提供更高的光合作用或水效率。本项目利用遗传学和分子生物学鉴定了几十个基因和基因产物在静脉模式形成过程中具有潜在的作用。目前的项目将继续了解这些关键基因产物的作用，其中一些是细胞内或细胞间信号传导的生化途径的成员（例如固醇）。这些信号的目标是什么，是什么在正确的时间和地点触发它们形成静脉细胞的连续文件？该项目将确定这些信号的直接触发点和目标，利用目前已确定的基因产物找到未知的基因产物，并引导到其他伙伴。这对科学的影响将是增加对脉脉形成的理解，为修改植物对不同环境的适应或植物生长效率提供潜在的工具。该项目更广泛的影响是，它可以作为研究生和博士后科学家的培训工具，并作为PI对本科生和研究生教学的材料来源。PI积极向非理工科本科生教授生物学，其中许多人对科学政策和科学与社会问题感兴趣。