Molecular dissection of plant defense responses to necrotrophic pathogens

植物对坏死性病原体防御反应的分子剖析

基本信息

  • 批准号:
    0422702
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2004
  • 资助国家:
    美国
  • 起止时间:
    2004-08-15 至 2008-07-31
  • 项目状态:
    已结题

项目摘要

Plant diseases caused by necrotrophic pathogens result in losses amounting to millions of dollars a year. Necrotrophic fungi actively kill host tissue prior to colonization usually through the secretion of toxins. This is in contrast to biotrophic pathogens that require living host cells to complete their life cycle. One of the most prevalent and damaging necrotrophs is Botrytis cinerea, a fungal pathogen which causes a variety of pre- and post-harvest diseases in a number of plant species. The principal means of protection against Botrytis is chemical disease control; however, it is seriously hampered by the emergence of fungicide resistance in the pathogen and consumer concern over residual activity in the produce and in the environment. Genetic resistance would be most desirable, but at present it is limited because of paucity of information on genes and mechanisms that underlie host resistance to Botrytis.The goal of this project is to gain insight into the molecular and cellular factors that play a crucial role in defense responses to Botrytis. Through a combination of genetic and genomic approaches many loci that control host response to the pathogen have been uncovered. One of these, BOS1 (Botrytis susceptible 1), was isolated and encodes an R2R3MYB transcription factor required for restricting Botrytis growth in infected plants. This proposal seeks to elucidate the function of BOS1 by determining what genes and pathways it impacts or modulates to regulate an important and relatively less understood arm of the Arabidopsis defense response. This proposal is likely to add tremendously to our understanding of how plants recognize and respond to attack by Botrytis and other necrotrophic fungi, opening the way for future advances in this area. A better appreciation of genes and mechanisms by which plants contend with necrotrophic pathogens will reveal new and effective ways for managing diseases caused by such pathogens. Such knowledge will help direct the breeding of Botrytis resistant cultivars for safe and sustainable crop protection. Ultimately, public safety and environmental quality will be enhanced. In addition, this project will provide ample opportunities for engaging and training students at all levels of education in the principles and applications of genetic, molecular, and plant pathology research, and for enhancing diversity in education.
由坏死性病原体引起的植物疾病每年造成高达数百万美元的损失。坏死性真菌在定植前主动杀死宿主组织,通常通过分泌毒素来杀死宿主组织。这与生物营养型病原体不同,后者需要活的宿主细胞来完成它们的生命周期。最普遍和最具破坏性的坏死菌之一是灰霉病菌,它是一种真菌病原体,在许多植物物种中引起各种收获前和收获后的疾病。预防灰霉病的主要手段是化学防治疾病;然而,由于病原菌中出现了对杀菌剂的抗药性,以及消费者对产品和环境中残留活性的担忧,这一方法受到了严重阻碍。遗传抗性将是最可取的,但目前它是有限的,因为缺乏关于寄主对灰霉病抗性的基因和机制的信息。本项目的目标是深入了解在对灰霉病的防御反应中起关键作用的分子和细胞因素。通过基因和基因组方法的结合,已经发现了许多控制寄主对病原体反应的基因座。其中BOS1(Botrytis Sensible 1)被分离出来,并编码一个R2R3MYB转录因子,该转录因子是限制灰霉病在受感染植物中生长所必需的。这一建议试图通过确定BOS1影响或调节哪些基因和途径来调节拟南芥防御反应的一个重要的、相对较少被理解的臂来阐明BOS1的功能。这一建议可能会极大地增加我们对植物如何识别和响应灰霉病和其他坏死性真菌攻击的理解,为这一领域的未来进展开辟道路。更好地了解植物与坏死性病原体抗争的基因和机制,将揭示管理由此类病原体引起的疾病的新的有效方法。这些知识将有助于指导抗灰霉病品种的选育,以实现安全和可持续的作物保护。最终,公共安全和环境质量将得到提高。此外,该项目将提供充足的机会,让各级教育的学生参与和培训遗传学、分子和植物病理学研究的原理和应用,并加强教育的多样性。

项目成果

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Tesfaye Mengiste其他文献

Killing softly: a roadmap of emBotrytis cinerea/em pathogenicity
轻柔地杀戮:灰葡萄孢菌致病性路线图
  • DOI:
    10.1016/j.tplants.2022.08.024
  • 发表时间:
    2023-02-01
  • 期刊:
  • 影响因子:
    20.800
  • 作者:
    Kai Bi;Yong Liang;Tesfaye Mengiste;Amir Sharon
  • 通讯作者:
    Amir Sharon
Pathogenic strategies and immune mechanisms to necrotrophs: Differences and similarities to biotrophs and hemibiotrophs
  • DOI:
    10.1016/j.pbi.2022.102291
  • 发表时间:
    2022-10-01
  • 期刊:
  • 影响因子:
    7.500
  • 作者:
    Chao-Jan Liao;Sara Hailemariam;Amir Sharon;Tesfaye Mengiste
  • 通讯作者:
    Tesfaye Mengiste
CDK8 is associated with RAP2.6 and SnRK2.6 and positively modulates abscisic acid signaling and drought response in Arabidopsis
CDK8 与 RAP2.6 和 SnRK2.6 相关,并正向调节拟南芥中的脱落酸信号传导和干旱反应
  • DOI:
    10.1111/nph.16787
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Yingfang Zhu;Pengcheng Huang;Pengcheng Guo;Leelyn Chong;Gaobo Yu;Xiaoli Sun;Tao Hu;Yuan Li;Chuan-Chih Hsu;Kai Tang;Yun Zhou;Chunzhao Zhao;Wei Gao;W Andy Tao;Tesfaye Mengiste;Jian-Kang Zhu
  • 通讯作者:
    Jian-Kang Zhu
Receptor-like cytoplasmic kinases: orchestrating plant cellular communication
类受体胞质激酶:协调植物细胞间通讯
  • DOI:
    10.1016/j.tplants.2024.04.006
  • 发表时间:
    2024-10-01
  • 期刊:
  • 影响因子:
    20.800
  • 作者:
    Sara Hailemariam;Chao-Jan Liao;Tesfaye Mengiste
  • 通讯作者:
    Tesfaye Mengiste

Tesfaye Mengiste的其他文献

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{{ truncateString('Tesfaye Mengiste', 18)}}的其他基金

Plant immune signaling network: Connecting pathogen perception, chromatin modification and activation of immune responses.
植物免疫信号网络:连接病原体感知、染色质修饰和免疫反应激活。
  • 批准号:
    1916893
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
Untangling the Complex Network of BIK1 Mediated Immune Response Signaling Pathways
解开 BIK1 介导的免疫反应信号通路的复杂网络
  • 批准号:
    1456594
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
Histone Modifications and Mediator Complex in Plant Innate Immunity to Necrotrophic Fungi
植物对坏死性真菌的先天免疫中的组蛋白修饰和介导复合物
  • 批准号:
    1050095
  • 财政年份:
    2011
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
Genetic, Molecular and Biochemical Basis of Pathogen and Stress Induced Necrosis
病原体和应激性坏死的遗传、分子和生化基础
  • 批准号:
    0749865
  • 财政年份:
    2008
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
The Role of Receptor Like Cytoplasmic Kinase Mediated Signaling in Plant Responses to Necrotrophic and Biotrophic Pathogens
受体样细胞质激酶介导的信号在植物对坏死性和生物营养性病原体的反应中的作用
  • 批准号:
    0618897
  • 财政年份:
    2007
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant

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