NSEC: Center for Affordable Nanoengineering of Polymer Biomedical Devices (CANPBD)

NSEC：经济实惠的聚合物生物医学设备纳米工程中心 (CANPBD)

• 批准号: 0425626
• 负责人: Ly James Lee
• 金额: $ 257.3万
• 依托单位: Ohio State University Research Foundation -DO NOT USE
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0425626&HistoricalAwards=false
• 关键词: NSEC; Center; Affordable; Nanoengineering; Polymer

The Nanoscale Science and Engineering Center entitled Center for Affordable Nanoengineering of Polymer Biomedical Devices (CANBD) is a partnership between the U. of Akron, Boston University, UC Berkeley, Johns Hopkins, Florida A&M, and Purdue. The NSEC includes 38 investigators from 9 departments. The Center seeks to develop polymer-based low-cost nanoengineering technology that can be used to produce nanofluidic devices and multifunctional polymer-nanoparticle-biomolecule nanostructures for the next generation medical diagnostic and therapeutic applications. The research plan is comprised of three thrust areas. The Nanomanufacturing Thrust Area combines 'top-down' fabrication and 'bottom-up' molecular self-assembly to produce well-defined passive and active nanostructures. In the Transport Phenomena Thrust Area, the research will achieve design capabilities at the nanoscale by combining nanofluidic design, transport phenomena at the nanoscale, and multiphase transport structures with multiscale modeling and macroscalar property assessment. Biocompatibility issues will be addressed in the Biocompatibility Thrust Area in parallel with the development of new nanofluidic designs and devices. The near-term goal of the three closely linked research thrust areas is to design and fabricate polymer-based, 3D nanofluidic circuits for manipulating the shape, orientation and transport behavior of individual biomolecules in well-defined nanoscale flow fields (5-100 nm). Test bed examples include a simple, handheld protein separation/diagnostic device; a nanoneedle cell patch for low-invasive delivery of genes and macromolecular medicines into cell walls; and biomolecular nanopumps as synthetic ion channels. The ultimate goal is to design and assemble a nanofactory based on the integration of nanofluidic circuits, synthetic chemistry and biological complexation.Center collaborators include at least 20 companies in Ohio and the U.S., Battelle, the Cleveland Clinic Foundation, the National Cancer Institute, Oak Ridge National Laboratory, Wright Patterson Air Force Labs, and researchers in Asia, Australia and Europe. The Center also plans to coordinate closely with NSECs at the University of California at Los Angeles and the University of Illinois-Urbana (nanomanufacturing), the NSF STC at the University of North Carolina at Chapel Hill (environmentally responsible solvents), and the NSF ERCs at the University of Washington (biomaterials and biocompatibility) and the Georgia Institute of Technology (3D tissue models) because of complementary research agendas. The education and outreach vision of the Center is to integrate the latest research developments into a practical student curriculum that imparts multidisciplinary skills and global awareness to both graduate and undergraduate students. The key education elements include a series of new courses to introduce nanoengineering of biomedical devices and related topics; an interdisciplinary curriculum offering an undergraduate minor and a graduate certificate; internships and visits to industry and national laboratories in the U.S. and abroad; and web-based dissemination. The recruitment and retention of minorities and women will be emphasized through close collaboration with minority institutes such as FAMU/FSU. Undergraduate students will participate in research via senior honors theses and targeted REU support. Outreach activities include web-based science modules for K-12 students nationwide; workshops and short courses for high school science teachers and industrial researchers; and on-site research projects and workshops for middle school and high school students supervised by graduate students.

纳米科学与工程中心名为高分子生物医学设备可负担纳米工程中心（CANBD），是由阿克伦大学、波士顿大学、加州大学伯克利分校、约翰霍普金斯大学、佛罗里达农工大学和普渡大学合作成立的。NSEC包括来自9个部门的38名调查人员。该中心旨在开发基于聚合物的低成本纳米工程技术，用于生产纳米流体装置和多功能聚合物-纳米颗粒-生物分子纳米结构，用于下一代医学诊断和治疗应用。研究计划由三个重点领域组成。纳米制造推力区结合了“自上而下”的制造和“自下而上”的分子自组装，以生产明确的被动和主动纳米结构。在输运现象推力领域，通过将纳米流体设计、纳米输运现象和多相输运结构与多尺度建模和宏观尺度性质评估相结合，实现纳米尺度的设计能力。生物相容性问题将在生物相容性推力领域与新的纳米流体设计和设备的发展并行解决。这三个密切相关的研究领域的近期目标是设计和制造基于聚合物的3D纳米流体电路，用于在明确定义的纳米尺度流场（5-100纳米）中操纵单个生物分子的形状、取向和传输行为。测试台的例子包括简单的手持式蛋白质分离/诊断设备；用于将基因和大分子药物低侵入性递送到细胞壁的纳米针细胞贴片生物分子纳米泵作为合成离子通道。最终目标是设计和组装一个基于纳米流体电路、合成化学和生物络合的纳米工厂。该中心的合作者包括俄亥俄州和美国的至少20家公司、巴特尔、克利夫兰诊所基金会、国家癌症研究所、橡树岭国家实验室、赖特帕特森空军实验室以及亚洲、澳大利亚和欧洲的研究人员。由于互补的研究议程，该中心还计划与加州大学洛杉矶分校和伊利诺伊大学厄巴纳分校的NSECs（纳米制造）、北卡罗来纳大学教堂山分校的NSF STC（环保溶剂）、华盛顿大学的NSF ERCs（生物材料和生物相容性）和佐治亚理工学院（3D组织模型）密切合作。该中心的教育和推广愿景是将最新的研究进展整合到实用的学生课程中，为研究生和本科生传授多学科技能和全球意识。主要教学内容包括一系列介绍生物医学设备纳米工程及相关课题的新课程；提供本科辅修课程和研究生证书的跨学科课程；在美国和国外的工业和国家实验室实习和参观；以及网络传播。将通过与FAMU/FSU等少数民族研究所密切合作，强调少数民族和妇女的征聘和留用。本科生将通过高级荣誉论文和有针对性的REU支持参与研究。拓展活动包括面向全国K-12学生的网络科学模块；为高中科学教师和工业研究人员举办的讲习班和短期课程；以及由研究生指导的初高中学生的现场研究项目和研讨会。