A Renewal Proposal for the Nanoscale Science and Engineering Center (NSEC) for Affordable Nanoengineering of Polymeric Biomedical Devices

高分子生物医学设备可负担纳米工程中心正在研究低成本、基于高分子的纳米技术，该技术可用于制造多功能纳米结构和纳米流体设备，用于下一代医学诊断和治疗应用。中心吗?他的研究集中在聚合物纳米工程和纳米流体之间的界面，导致两条实用的纳米工厂装配线，一条基于纳米流体网络，另一条基于静电纺纳米纤维。一条纳米工厂装配线将纳米材料和纳米技术连接起来，使细胞、生物分子和纳米颗粒能够沿着预先指定的路径形成和运输。组装线吗?具有可控的运动和结构。它允许连续生产多功能仿生纳米结构，单个细胞的非随机转染和分子分析，以及基于3D细胞的设备。这些纳米工厂将大大提高通过基因组学和蛋白质组学研究发现的新药和基因的性能，用于治疗癌症、传染病和寄生虫病、慢性病和遗传疾病。第二阶段有三个主要的科学挑战：1)聚合物性质的纳米级表征和建模，2)纳米级聚合物-生物分子界面相互作用，以及3)纳米级和多尺度流体学和建模。这些科学研究将使：(1)可负担且生物良性的3D聚合物纳米结构制造，(2)聚合物和生物分子纳米结构的引导组装，(3)主动纳米流体设计，以及(4)基于磁镊子、光镊子波导和电化学浸笔纳米光刻悬臂阵列的生物分子、细胞和纳米颗粒操纵装置阵列。建议活动的社会影响如下：(1)通过经济实惠的制造方法和新颖的设计将新的纳米生物医学设备商业化；(2)将医学/生物学应用的研究成果扩展到功能性纳米复合材料、水处理、国土安全、环境保护和食品工业毒理学；(3)建立新产品和新产业，在美国创造高薪工作岗位；(4)在经济上重要和关键的高科技领域培养21世纪的劳动力。

ABSTRACTThe Center for Affordable Nanoengineering of Polymeric Biomedical Devices is researching low-cost, polymer-based nanotechnologies that can be used to manufacture multifunctional nanostructures and nanofluidic devices for next generation medical diagnostic and therapeutic applications. The Center?s research concentrates on the interface between polymer nanoengineering and nanofluidics, leading to two practical nanofactory assembly lines, one based on nanofluidic network and the other on electrospun nanofibers. A nanofactory assembly line links nanomaterials and nanotechnologies to allow cells, biomolecules and nanoparticles to be formed and transported along a pre-specified ?assembly line? with controlled motion and structure. It allows continuous production of multi-functional biomimetic nanostructures, non-stochastic transfection and molecular analysis of individual cells, and 3D cell-based devices. These nanofactories will greatly enhance the performance of new drugs and genes discovered through genomics and proteomics research for the treatment of cancer, infectious and parasitological disease, chronic illness, and genetic disorders. There are three major scientific challenges in Phase II: 1) nanoscale characterization and modeling of polymer properties, 2) interfacial polymer-biomolecule interactions at the nanoscale, and 3) nanoscale and multiscale fluidics and modeling These scientific studies will enable: (1) affordable and biologically benign fabrication of 3D polymer nanoconstructs, (2) guided assembly of polymer and biomolecule nanostructures, (3) active nanofluidic designs, and (4) arrays of devices for the manipulation of biomolecules, cells and nanoparticles, based on magnetic tweezers, optical tweezer wave guides, and electrochemical dip-pen nanolithography cantilever arrays. The societal impacts of the proposed activities are to: (1) commercialize new nanoengineered biomedical devices through affordable manufacturing methods and novel design, (2) extend research results from medical/biology applications to functional nanocomposites, water treatment, homeland security, environmental protection, and food industry toxicology, (3) establish new products and new industries to create high-paying jobs in the U.S., and (4) train the 21st century workforce in economically important and critical high-tech fields.